The roles of helix I and strand 5A in the folding, function and misfolding of α1-antitrypsin.

by Anja S Knaupp, Shani Keleher, Li Yang, Weiwen Dai, Stephen P Bottomley, Mary C Pearce
Published 2013-01-01

Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1

by Onisha Patel, Michael J. Roy, Ashleigh Kropp, Joshua M. Hardy, Weiwen Dai, Isabelle S. Lucet
Published 2021-09-01

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein

by Brad E. Sleebs, Kate E. Jarman, Sonja Frolich, Wilson Wong, Julie Healer, Weiwen Dai, Isabelle S. Lucet, Danny W. Wilson, Alan F. Cowman
Published 2020-12-01

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

by Onisha Patel, Michael D. W. Griffin, Santosh Panjikar, Weiwen Dai, Xiuquan Ma, Howard Chan, Celine Zheng, Ashleigh Kropp, James M. Murphy, Roger J. Daly, Isabelle S. Lucet
Published 2017-10-01

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

by Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb, James M. Murphy
Published 2018-06-01