Intrapopulation analysis of longitudinal lifespan in Caenorhabditis elegans identifies W09D10.4 as a novel AMPK-associated healthspan shortening factor

by Yoshio Nakano, Masataka Moriuchi, Yutaro Fukushima, Kyotaro Hayashi, Mary Ann Suico, Hirofumi Kai, Go Koutaki, Tsuyoshi Shuto
Published 2021-03-01

Evaluation of Three-Dimensional Cultured HepG2 Cells in a Nano Culture Plate System: an In Vitro Human Model of Acetaminophen Hepatotoxicity

by Kohei Aritomi, Yoichi Ishitsuka, Yoshiro Tomishima, Daisuke Shimizu, Nazuki Abe, Tsuyoshi Shuto, Mitsuru Irikura, Hirofumi Kai, Tetsumi Irie
Published 2014-01-01

Characterization of the Trafficking Pathway of Cystic Fibrosis Transmembrane Conductance Regulator in Baby Hamster Kidney Cells

by Tsukasa Okiyoneda, Kazutsune Harada, Kaori Yamahira, Ikuo Wada, Yasuaki Hashimoto, Keiko Ueno, Mary Ann Suico, Tsuyoshi Shuto, Hirofumi Kai
Published 2004-01-01

Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione

by Takeshi Yokoyama, Shun Takaki, Keisuke Chosa, Takashi Sato, Mary Ann Suico, Yuriko Teranishi, Tsuyoshi Shuto, Mineyuki Mizuguchi, Hirofumi Kai
Published 2015-12-01

Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome.

by Tomoaki Koga, Yukari Kai, Ryosuke Fukuda, Saori Morino-Koga, Mary Ann Suico, Kosuke Koyama, Takashi Sato, Tsuyoshi Shuto, Hirofumi Kai
Published 2012-01-01

Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants

by Sara Mustafa Idris Elbashir, Hari Prasad Devkota, Mikiyo Wada, Naoki Kishimoto, Masataka Moriuchi, Tsuyoshi Shuto, Shogo Misumi, Hirofumi Kai, Takashi Watanabe
Published 2018-10-01

Mild Electrical Stimulation Increases Ubiquitinated Proteins and Hsp72 in A549 Cells via Attenuation of Proteasomal Degradation

by Saori Morino, Mary Ann Suico, Tatsuya Kondo, Erika Sekimoto, Shuichiro Yano, Tomoko Matsuda, Takashi Matsuno, Tsuyoshi Shuto, Eiichi Araki, Hirofumi Kai
Published 2008-01-01

Trimerization and Genotype–Phenotype Correlation of COL4A5 Mutants in Alport Syndrome

by Misato Kamura, Tomohiko Yamamura, Kohei Omachi, Mary Ann Suico, Kandai Nozu, Shota Kaseda, Jun Kuwazuru, Tsuyoshi Shuto, Kazumoto Iijima, Hirofumi Kai
Published 2020-05-01

Bromide supplementation exacerbated the renal dysfunction, injury and fibrosis in a mouse model of Alport syndrome.

by Tsubasa Yokota, Kohei Omachi, Mary Ann Suico, Haruka Kojima, Misato Kamura, Keisuke Teramoto, Shota Kaseda, Jun Kuwazuru, Tsuyoshi Shuto, Hirofumi Kai
Published 2017-01-01

Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.

by Saori Morino, Tatsuya Kondo, Kazunari Sasaki, Hironori Adachi, Mary Ann Suico, Erika Sekimoto, Tomoko Matsuda, Tsuyoshi Shuto, Eiichi Araki, Hirofumi Kai
Published 2008-01-01

The Regulation of Human β-Defensin 2 by the ETS Transcription Factor MEF (Myeloid Elf-1-Like Factor) Is Enhanced by Promyelocytic Leukemia Protein

by Mary Ann Suico, Zhuo Lu, Tsuyoshi Shuto, Tomoaki Koga, Tomoko Uchikawa, Hiroki Yoshida, Kazuhito Matsuzaki, Mitsuyoshi Nakao, Jian-Dong Li, Hirofumi Kai
Published 2004-01-01

Mild electrical stimulation increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway in C. elegans.

by Shingo Matsuyama, Masataka Moriuchi, Mary Ann Suico, Shuichiro Yano, Saori Morino-Koga, Tsuyoshi Shuto, Kunitoshi Yamanaka, Tatsuya Kondo, Eiichi Araki, Hirofumi Kai
Published 2014-01-01

Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from <i>Juglans mandshurica</i> Maxim. var. <i>cordiformis</i> (Makino) Kitam.

by Niraj Chaudhary, Ryoko Sasaki, Tsuyoshi Shuto, Masato Watanabe, Teppei Kawahara, Mary Ann Suico, Takeshi Yokoyama, Mineyuki Mizuguchi, Hirofumi Kai, Hari Prasad Devkota
Published 2019-01-01

A novel condition of mild electrical stimulation exerts immunosuppression via hydrogen peroxide production that controls multiple signaling pathway.

by Mariam Piruzyan, Ihori Shitanda, Yuichiro Shimauchi, Go Okita, Yu Tsurekawa, Masataka Moriuchi, Yoshio Nakano, Keisuke Teramoto, Mary Ann Suico, Tsuyoshi Shuto, Hirofumi Kai
Published 2020-01-01

Synergism Between Interleukin (IL)-17 and Toll-like Receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells

by Shota Mizunoe, Tsuyoshi Shuto, Shingo Suzuki, Chizuru Matsumoto, Kenji Watanabe, Keiko Ueno-Shuto, Mary Ann Suico, Kouhei Onuki, Dieter C. Gruenert, Hirofumi Kai
Published 2012-01-01

The role of discoidin domain receptor 2 in the renal dysfunction of alport syndrome mouse model

by Yuya Sannomiya, Shota Kaseda, Misato Kamura, Hiroshi Yamamoto, Hiroyuki Yamada, Masataka Inamoto, Jun Kuwazuru, Saki Niino, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai
Published 2021-01-01

Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K) / Akt Pathway

by Shuichiro Yano, Saori Morino-Koga, Tatsuya Kondo, Mary Ann Suico, Tomoaki Koga, Yuichiro Shimauchi, Shingo Matsuyama, Tsuyoshi Shuto, Takashi Sato, Eiichi Araki, Hirofumi Kai
Published 2011-01-01

Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases

by Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico, Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto
Published 2019-06-01

Metformin ameliorates the severity of experimental Alport syndrome

by Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Published 2021-03-01

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells

by Shunsuke Kamei, Haruka Fujikawa, Hirofumi Nohara, Keiko Ueno-Shuto, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Chizuru Matsumoto, Yuki Sakaguchi, Tomomi Ono, Mary Ann Suico, Richard C. Boucher, Dieter C. Gruenert, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Hirofumi Kai, Tsuyoshi Shuto
Published 2018-01-01