Superovulation using the combined administration of inhibin antiserum and equine chorionic gonadotropin increases the number of ovulated oocytes in C57BL/6 female mice.

by Toru Takeo, Naomi Nakagata
Published 2015-01-01

N-acetyl cysteine restores the fertility of vitrified-warmed mouse oocytes derived through ultrasuperovulation.

by Ayumi Mukunoki, Toru Takeo, Naomi Nakagata
Published 2019-01-01

Cryopreservation of mouse resources

by Toru Takeo, Satohiro Nakao, Yoshiko Nakagawa, Jorge M. Sztein, Naomi Nakagata
Published 2020-09-01

Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice

by Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Published 2017-05-01

Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice

by Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Published 2016-08-01

Tsukushi is essential for the development of the inner ear

by Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song, Ryosei Minoda
Published 2020-03-01

Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann–Pick Type C disease models

by Yuta Tanaka, Yoichi Ishitsuka, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Published 2014-01-01

Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis

by Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Yuka Horikoshi, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yuki Kondo, Yoichi Ishitsuka, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Published 2016-02-01

Auto-measure emphysematous parameters and pathophysiological gene expression profiles in experimental mouse models of acute and chronic obstructive pulmonary diseases

by Ryunosuke Nakashima, Shunsuke Kamei, Hirofumi Nohara, Haruka Fujikawa, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Mary Ann Suico, Toru Takeo, Naomi Nakagata, Hirofumi Kai, Tsuyoshi Shuto
Published 2019-06-01

In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease

by Yuki Maeda, Keiichi Motoyama, Rena Nishiyama, Taishi Higashi, Risako Onodera, Hideaki Nakamura, Toru Takeo, Naomi Nakagata, Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Published 2019-05-01

An acute phase protein α1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action

by Hiroshi Watanabe, Rui Fujimura, Yuto Hiramoto, Ryota Murata, Kento Nishida, Jing Bi, Tadashi Imafuku, Hisakazu Komori, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Published 2021-04-01

A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein

by Hiroshi Watanabe, Jing Bi, Ryota Murata, Rui Fujimura, Kento Nishida, Tadashi Imafuku, Yuka Nakamura, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Published 2020-07-01

Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–P...

by Madoka Fukaura, Yoichi Ishitsuka, Seiichi Shirakawa, Naoki Ushihama, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Katsumi Higaki, Muneaki Matsuo, Tetsumi Irie
Published 2021-01-01

Metformin ameliorates the severity of experimental Alport syndrome

by Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Published 2021-03-01

In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C

by Nushrat Yasmin, Yoichi Ishitsuka, Madoka Fukaura, Yusei Yamada, Shuichi Nakahara, Akira Ishii, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Yasuyo Okada, Junichi Nishikawa, Atsushi Ichikawa, Daisuke Iohara, Fumitoshi Hirayama, Katsumi Higaki, Kousaku Ohno, Muneaki Matsuo, Tetsumi Irie
Published 2019-03-01

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells

by Shunsuke Kamei, Haruka Fujikawa, Hirofumi Nohara, Keiko Ueno-Shuto, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Chizuru Matsumoto, Yuki Sakaguchi, Tomomi Ono, Mary Ann Suico, Richard C. Boucher, Dieter C. Gruenert, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Hirofumi Kai, Tsuyoshi Shuto
Published 2018-01-01

Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function

by Haruka Fujikawa, Yuki Sakamoto, Natsuki Masuda, Kentaro Oniki, Shunsuke Kamei, Hirofumi Nohara, Ryunosuke Nakashima, Kasumi Maruta, Taisei Kawakami, Yuka Eto, Noriki Takahashi, Toru Takeo, Naomi Nakagata, Hiroshi Watanabe, Koji Otake, Yasuhiro Ogata, Naoko H. Tomioka, Makoto Hosoyamada, Tappei Takada, Keiko Ueno-Shuto, Mary Ann Suico, Hirofumi Kai, Junji Saruwatari, Tsuyoshi Shuto
Published 2020-05-01