A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients

by Ricardo Khouri, Gilvanéia Silva-Santos, Tim Dierckx, Soraya Maria Menezes, Daniele Decanine, Kristof Theys, Aline Clara Silva, Lourdes Farré, Achiléa Bittencourt, Massimo Mangino, Mario Roederer, Anne-Mieke Vandamme, Johan Van Weyenbergh
Published 2018-05-01

XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis

by Eline Boons, Tatiane C. Nogueira, Tim Dierckx, Soraya Maria Menezes, Maarten Jacquemyn, Sharon Tamir, Yosef Landesman, Lourdes Farré, Achiléa Bittencourt, Keisuke Kataoka, Seishi Ogawa, Robert Snoeck, Graciela Andrei, Johan Van Weyenbergh, Dirk Daelemans
Published 2021-02-01

Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

by Britta Moens, Daniele Decanine, Soraya Maria Menezes, Ricardo Khouri, Gilvanéia Silva-Santos, Giovanni Lopez, Carolina Alvarez, Michael Talledo, Eduardo Gotuzzo, Ramon de Almeida Kruschewsky, Bernardo Galvão-Castro, Anne-Mieke Vandamme, Anne-Mieke Vandamme, Johan Van Weyenbergh
Published 2012-01-01

Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-β Response in HTLV-1-Associated Neuroinflammation

by Fabio E. Leal, Fabio E. Leal, Soraya Maria Menezes, Emanuela A. S. Costa, Phillip M. Brailey, Lucio Gama, Aluisio C. Segurado, Esper G. Kallas, Douglas F. Nixon, Tim Dierckx, Ricardo Khouri, Ricardo Khouri, Jurgen Vercauteren, Bernardo Galvão-Castro, Rui Andre Saraiva Raposo, Johan Van Weyenbergh
Published 2018-05-01