Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors

by Stephane Angers
Published 2021-04-01

Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.

by Renyue Bao, Tania Christova, Siyuan Song, Stephane Angers, Xiaojun Yan, Liliana Attisano
Published 2012-01-01

Identification of Novel Smoothened Ligands Using Structure-Based Docking.

by Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers
Published 2016-01-01

Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.

by Sarah H Louie, Xiao Yong Yang, William H Conrad, Jeanot Muster, Stephane Angers, Randall T Moon, Benjamin N R Cheyette
Published 2009-01-01

The Pseudomonas syringae type III effector HopF2 suppresses Arabidopsis stomatal immunity.

by Brenden Hurley, Donghyuk Lee, Adam Mott, Michael Wilton, Jun Liu, Yulu C Liu, Stephane Angers, Gitta Coaker, David S Guttman, Darrell Desveaux
Published 2014-01-01

Identifying chemogenetic interactions from CRISPR screens with drugZ

by Medina Colic, Gang Wang, Michal Zimmermann, Keith Mascall, Megan McLaughlin, Lori Bertolet, W. Frank Lenoir, Jason Moffat, Stephane Angers, Daniel Durocher, Traver Hart
Published 2019-08-01

The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity.

by Junfeng Han, Ming Zhang, Sean Froese, Feihan F Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B Wheeler, Li Wei
Published 2015-01-01

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

by Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu
Published 2019-08-01

A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion.

by Amy Huei-Yi Lee, Brenden Hurley, Corinna Felsensteiner, Carmen Yea, Wenzislava Ckurshumova, Verena Bartetzko, Pauline W Wang, Van Quach, Jennifer D Lewis, Yulu C Liu, Frederik Börnke, Stephane Angers, Andrew Wilde, David S Guttman, Darrell Desveaux
Published 2012-02-01

The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs

by John D. Laver, Jimmy Ly, Allison K. Winn, Angelo Karaiskakis, Sichun Lin, Kun Nie, Giulia Benic, Nima Jaberi-Lashkari, Wen Xi Cao, Alireza Khademi, J. Timothy Westwood, Sachdev S. Sidhu, Quaid Morris, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz
Published 2020-03-01

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

by Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Published 2020-07-01

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells

by Graham MacLeod, Danielle A. Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi, Zachary Steinhart, Michelle M. Kushida, Helen Yu, Fiona J. Coutinho, Florence M.G. Cavalli, Ian Restall, Xiaoguang Hao, Traver Hart, H. Artee Luchman, Samuel Weiss, Peter B. Dirks, Stephane Angers
Published 2019-04-01

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

by Paul Guilhamon, Charles Chesnelong, Michelle M Kushida, Ana Nikolic, Divya Singhal, Graham MacLeod, Seyed Ali Madani Tonekaboni, Florence MG Cavalli, Christopher Arlidge, Nishani Rajakulendran, Naghmeh Rastegar, Xiaoguang Hao, Rozina Hassam, Laura J Smith, Heather Whetstone, Fiona J Coutinho, Bettina Nadorp, Katrina I Ellestad, H Artee Luchman, Jennifer Ai-wen Chan, Molly S Shoichet, Michael D Taylor, Benjamin Haibe-Kains, Samuel Weiss, Stephane Angers, Marco Gallo, Peter B Dirks, Mathieu Lupien
Published 2021-01-01