Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors

by Christopher DeRenzo, Stephen Gottschalk
Published 2019-02-01

Engineered Cytokine Signaling to Improve CAR T Cell Effector Function

by Matthew Bell, Matthew Bell, Stephen Gottschalk
Published 2021-06-01

Foreign or Domestic CARs: Receptor Ligands as Antigen-Binding Domains

by Donald R. Shaffer, Penghui Zhou, Stephen Gottschalk
Published 2014-01-01

Harnessing T Cells to Target Pediatric Acute Myeloid Leukemia: CARs, BiTEs, and Beyond

by Rebecca Epperly, Stephen Gottschalk, Mireya Paulina Velasquez
Published 2020-02-01

Allogeneic CAR Cell Therapy—More Than a Pipe Dream

by Kenneth J. Caldwell, Stephen Gottschalk, Aimee C. Talleur
Published 2021-01-01

A Bump in the Road: How the Hostile AML Microenvironment Affects CAR T Cell Therapy

by Rebecca Epperly, Rebecca Epperly, Stephen Gottschalk, M. Paulina Velasquez
Published 2020-02-01

Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models

by Marianna Csaplár, János Szöllősi, Stephen Gottschalk, György Vereb, Árpád Szöőr
Published 2021-08-01

Optimizing EphA2-CAR T Cells for the Adoptive Immunotherapy of Glioma

by Zhongzhen Yi, Brooke L. Prinzing, Felicia Cao, Stephen Gottschalk, Giedre Krenciute
Published 2018-06-01

A vaccine that co-targets tumor cells and cancer associated fibroblasts results in enhanced antitumor activity by inducing antigen spreading.

by Stephen Gottschalk, Feng Yu, Minjun Ji, Sunitha Kakarla, Xiao-Tong Song
Published 2013-01-01

MyD88/CD40 signaling retains CAR T cells in a less differentiated state

by Brooke Prinzing, Patrick Schreiner, Matthew Bell, Yiping Fan, Giedre Krenciute, Stephen Gottschalk
Published 2020-11-01

Chimeric Antigen Receptor Signaling Domains Differentially Regulate Proliferation and Native T Cell Receptor Function in Virus-Specific T Cells

by Bilal Omer, Bilal Omer, Paul A. Castillo, Haruko Tashiro, Thomas Shum, Mai T. A. Huynh, Mara Cardenas, Miyuki Tanaka, Andrew Lewis, Tim Sauer, Robin Parihar, Robin Parihar, Natalia Lapteva, Michael Schmueck-Henneresse, Malini Mukherjee, Stephen Gottschalk, Stephen Gottschalk, Stephen Gottschalk, Cliona M. Rooney, Cliona M. Rooney, Cliona M. Rooney, Cliona M. Rooney
Published 2018-12-01

In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy

by Robert L. Kruse, Thomas Shum, Xavier Legras, Mercedes Barzi, Frank P. Pankowicz, Stephen Gottschalk, Karl-Dimiter Bissig
Published 2017-12-01

T Cell-Activating Mesenchymal Stem Cells as a Biotherapeutic for HCC

by Arpad Szoor, Abishek Vaidya, Mireya Paulina Velasquez, Zhuyong Mei, Daniel L. Galvan, David Torres, Adrian Gee, Andras Heczey, Stephen Gottschalk
Published 2017-09-01

A Novel Orthotopic Implantation Technique for Osteosarcoma Produces Spontaneous Metastases and Illustrates Dose-Dependent Efficacy of B7-H3-CAR T Cells

by Lindsay Jones Talbot, Ashley Chabot, Amy Funk, Phuong Nguyen, Jessica Wagner, Aaron Ross, Heather Tillman, Andrew Davidoff, Stephen Gottschalk, Christopher DeRenzo
Published 2021-06-01

139 Establishment of canine CAR T cells treatment model for solid tumor immunotherapy development

by Peter Moore, Stephen Gottschalk, Shihong Zhang, Karan Kohli, R Graeme Black, Brian Hayes, Cassandra Miller, Mari Maeda-Whitaker, Brett Schroeder, Kraig Abrams, Bernard Seguin, Beverly Torok-Storb, Seth Pollack
Published 2020-11-01

The Art and Science of Selecting a CD123-Specific Chimeric Antigen Receptor for Clinical Testing

by Janice M. Riberdy, Sheng Zhou, Fei Zheng, Young-In Kim, Jennifer Moore, Abishek Vaidya, Robert E. Throm, April Sykes, Natasha Sahr, Challice L. Bonifant, Byoung Ryu, Stephen Gottschalk, Mireya Paulina Velasquez
Published 2020-09-01

Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells

by Phuong Nguyen, Emmanuel Okeke, Michael Clay, Dalia Haydar, Julie Justice, Carla O’Reilly, Shondra Pruett-Miller, James Papizan, Jennifer Moore, Sheng Zhou, Robert Throm, Giedre Krenciute, Stephen Gottschalk, Christopher DeRenzo
Published 2020-09-01

Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment.

by Vita S Salsman, Kevin K H Chow, Donald R Shaffer, Huseyin Kadikoy, Xiao-Nan Li, Claudia Gerken, Laszlo Perlaky, Leonid S Metelitsa, Xiuhua Gao, Meena Bhattacharjee, Karen Hirschi, Helen E Heslop, Stephen Gottschalk, Nabil Ahmed
Published 2011-01-01

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

by Zakaria Grada, Meenakshi Hegde, Tiara Byrd, Donald R Shaffer, Alexia Ghazi, Vita S Brawley, Amanda Corder, Kurt Schönfeld, Joachim Koch, Gianpietro Dotti, Helen E Heslop, Stephen Gottschalk, Winfried S Wels, Matthew L Baker, Nabil Ahmed
Published 2013-01-01

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

by Meenakshi Hegde, Sujith K. Joseph, Farzana Pashankar, Christopher DeRenzo, Khaled Sanber, Shoba Navai, Tiara T. Byrd, John Hicks, Mina L. Xu, Claudia Gerken, Mamta Kalra, Catherine Robertson, Huimin Zhang, Ankita Shree, Birju Mehta, Olga Dakhova, Vita S. Salsman, Bambi Grilley, Adrian Gee, Gianpietro Dotti, Helen E. Heslop, Malcolm K. Brenner, Winfried S. Wels, Stephen Gottschalk, Nabil Ahmed
Published 2020-07-01