HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model

by Kamira Maharaj, Kamira Maharaj, John J. Powers, Melanie Mediavilla-Varela, Alex Achille, Wael Gamal, Wael Gamal, Steven Quayle, Simon S. Jones, Eva Sahakian, Eva Sahakian, Javier Pinilla-Ibarz, Javier Pinilla-Ibarz
Published 2020-11-01

553 CUE-100 series Immuno-STATs from concept to the clinic: Leveraging protein engineering to stimulate and selectively deliver affinity-attenuated IL-2 to antigen-specific T cells...

by Saso Cemerski, Alex Histed, Natasha Girgis, Miguel Moreta, Jonathan Soriano, BS Luke Witt, Zohra Merazga, Fulvio Diaz, Fan Zhao, Melissa Kemp, Paige Ruthardt, Dharma Thapa, Anish Suri, Kenneth Pienta, Mary Simcox, Steven Quayle, John Ross
Published 2020-11-01