Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases

by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime
Published 2012-01-01

The Role of PPARs in Lung Fibrosis

by Heather F. Lakatos, Thomas H. Thatcher, R. Matthew Kottmann, Tatiana M. Garcia, Richard P. Phipps, Patricia J. Sime
Published 2007-01-01

PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

by Ajit A Kulkarni, Thomas H Thatcher, Keith C Olsen, Sanjay B Maggirwar, Richard P Phipps, Patricia J Sime
Published 2011-01-01

Cigarette smoke increases susceptibility to infection in lung epithelial cells by upregulating caveolin-dependent endocytosis.

by Parker F Duffney, A Karim Embong, Connor C McGuire, Thomas H Thatcher, Richard P Phipps, Patricia J Sime
Published 2020-01-01

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2.

by Amali P Epa, Thomas H Thatcher, Stephen J Pollock, Lindsay A Wahl, Elizabeth Lyda, R M Kottmann, Richard P Phipps, Patricia J Sime
Published 2015-01-01

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.

by Ajit A Kulkarni, Thomas H Thatcher, Hsi-Min Hsiao, Keith C Olsen, Robert Matthew Kottmann, Jason Morrissette, Terry W Wright, Richard P Phipps, Patricia J Sime
Published 2013-01-01

Electrophilic PPARγ Ligands Attenuate IL-1β and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPARγ-Independent Mechanism

by Christopher M. Hogan, Thomas H. Thatcher, Ramil E. Sapinoro, Michael N. Gurell, Heather E. Ferguson, Stephen J. Pollock, Carolyn Jones, Richard P. Phipps, Patricia J. Sime
Published 2011-01-01

A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation.

by Hsi-Min Hsiao, Ramil E Sapinoro, Thomas H Thatcher, Amanda Croasdell, Elizabeth P Levy, Robert A Fulton, Keith C Olsen, Stephen J Pollock, Charles N Serhan, Richard P Phipps, Patricia J Sime
Published 2013-01-01