Characterization of DNA G-Quadruplex Structures in Human Immunoglobulin Heavy Variable (IGHV) Genes

by Catherine Tang, Thomas MacCarthy, Thomas MacCarthy
Published 2021-05-01

Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots

by Artem Krantsevich, Catherine Tang, Thomas MacCarthy, Thomas MacCarthy
Published 2021-02-01

The preferred nucleotide contexts of the AID/APOBEC cytidine deaminases have differential effects when mutating retrotransposon and virus sequences compared to host genes.

by Jeffrey Chen, Thomas MacCarthy
Published 2017-03-01

Antagonistic Coevolution Drives Whack-a-Mole Sensitivity in Gene Regulatory Networks.

by Jeewoen Shin, Thomas MacCarthy
Published 2015-10-01

Mutational pressure by host APOBEC3s more strongly affects genes expressed early in the lytic phase of herpes simplex virus-1 (HSV-1) and human polyomavirus (HPyV) infection.

by Maxwell Shapiro, Laurie T Krug, Thomas MacCarthy
Published 2021-04-01

Epigenetics decouples mutational from environmental robustness. Did it also facilitate multicellularity?

by Saurabh Gombar, Thomas MacCarthy, Aviv Bergman
Published 2014-03-01

Correction to: The cytidine deaminase under-representation reporter (CDUR) as a tool to study evolution of sequences under deaminase mutational pressure

by Maxwell Shapiro, Stephen Meier, Thomas MacCarthy
Published 2018-07-01

The cytidine deaminase under-representation reporter (CDUR) as a tool to study evolution of sequences under deaminase mutational pressure

by Maxwell Shapiro, Stephen Meier, Thomas MacCarthy
Published 2018-05-01

The underlying molecular and network level mechanisms in the evolution of robustness in gene regulatory networks.

by Mario Pujato, Thomas MacCarthy, Andras Fiser, Aviv Bergman
Published 2013-01-01

Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.

by Aviv Bergman, Gil Atzmon, Kenny Ye, Thomas MacCarthy, Nir Barzilai
Published 2007-08-01

Regulatory evolution and voltage-gated ion channel expression in squid axon: selection-mutation balance and fitness cliffs.

by Min Kim, Don McKinnon, Thomas MacCarthy, Barbara Rosati, David McKinnon
Published 2015-01-01

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

by Catherine Tang, Davide Bagnara, Davide Bagnara, Nicholas Chiorazzi, Matthew D. Scharff, Thomas MacCarthy
Published 2020-04-01

The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.

by Chaohui Yuan, Charles C Chu, Xiao-Jie Yan, Davide Bagnara, Nicholas Chiorazzi, Thomas MacCarthy
Published 2017-01-01

A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks

by Umberto Rosani, Chang-Ming Bai, Lorenzo Maso, Maxwell Shapiro, Miriam Abbadi, Stefania Domeneghetti, Chong-Ming Wang, Laura Cendron, Thomas MacCarthy, Paola Venier
Published 2019-07-01

Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-B...

by Qiwen Dong, Kyle R. Smith, Darby G. Oldenburg, Maxwell Shapiro, William R. Schutt, Laraib Malik, Joshua B. Plummer, Yunxiang Mu, Thomas MacCarthy, Douglas W. White, Kevin M. McBride, Laurie T. Krug
Published 2018-10-01

STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.

by Michael T McIntosh, Siva Koganti, J Lucas Boatwright, Xiaofan Li, Salvatore V Spadaro, Alexis C Brantly, Jasmine B Ayers, Ramon D Perez, Eric M Burton, Sandeepta Burgula, Thomas MacCarthy, Sumita Bhaduri-McIntosh
Published 2020-10-01

STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes

by Michael T. McIntosh, Siva Koganti, J. Lucas Boatwright, Xiaofan Li, Salvatore V. Spadaro, Alexis C. Brantly, Jasmine B. Ayers, Ramon D. Perez, Eric M. Burton, Sandeepta Burgula, Thomas MacCarthy, Sumita Bhaduri-McIntosh, Nicholas Wallace
Published 2020-10-01

Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course

by Davide Bagnara, Davide Bagnara, Catherine Tang, Jennifer R. Brown, Siddha Kasar, Stacey Fernandes, Monica Colombo, Stefano Vergani, Andrea N. Mazzarello, Fabio Ghiotto, Fabio Ghiotto, Silvia Bruno, Fortunato Morabito, Fortunato Morabito, Kanti R. Rai, Kanti R. Rai, Jonathan E. Kolitz, Jonathan E. Kolitz, Jacqueline C. Barrientos, Jacqueline C. Barrientos, Steven L. Allen, Steven L. Allen, Franco Fais, Franco Fais, Matthew D. Scharff, Thomas MacCarthy, Nicholas Chiorazzi, Nicholas Chiorazzi
Published 2021-05-01