Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program

by Ping Wang, Connor M. Wander, Chao-Xing Yuan, Michael S. Bereman, Todd J. Cohen
Published 2017-07-01

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.

by Todd J Cohen, Brian H Constance, Andrew W Hwang, Michael James, Chao-Xing Yuan
Published 2016-01-01

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

by Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohen
Published 2016-01-01

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

by Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit, Jau-Shyong Hong, Xian Chen, Rick B. Meeker, Todd J. Cohen
Published 2017-08-01

Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat modelKey Findings

by Hebah Hassan, BS, Lisa V. Greco, MS, Daniel I. Meshoyrer, DO, Ying Li, BS, Youhua Zhang, MD, PhD, Todd J. Cohen, MD, FHRS
Published 2020-06-01

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

by Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen
Published 2020-07-01

An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

by Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen
Published 2020-11-01