Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling.

by Tatu Pantsar, Sami Rissanen, Daniel Dauch, Tuomo Laitinen, Ilpo Vattulainen, Antti Poso
Published 2018-09-01

Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors

by Agata Zięba, Tuomo Laitinen, Jayendra Z. Patel, Antti Poso, Agnieszka A. Kaczor
Published 2021-06-01

In Vitro and In Silico Evaluation of Bikaverin as a Potent Inhibitor of Human Protein Kinase CK2

by Samer Haidar, Dagmar Aichele, Robin Birus, Janine Hielscher, Tuomo Laitinen, Antti Poso, Joachim Jose
Published 2019-04-01

Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining

by Samer Haidar, Zouhair Bouaziz, Christelle Marminon, Tuomo Laitinen, Antti Poso, Marc Le Borgne, Joachim Jose
Published 2017-01-01

New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)

by Christopher R. M. Asquith, Tuomo Laitinen, Carrow I. Wells, Graham J. Tizzard, William J. Zuercher
Published 2020-04-01

Antimicrobial and Antifungal Activity of Rare Substituted 1,2,3-Thiaselenazoles and Corresponding Matched Pair 1,2,3-Dithiazoles

by Tuomo Laitinen, Ilia V. Baranovsky, Lidia S. Konstantinova, Antti Poso, Oleg A. Rakitin, Christopher R. M. Asquith
Published 2020-07-01

Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).

by Juha R Savinainen, Jayendra Z Patel, Teija Parkkari, Dina Navia-Paldanius, Joona J T Marjamaa, Tuomo Laitinen, Tapio Nevalainen, Jarmo T Laitinen
Published 2014-01-01

Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12).

by Teija Parkkari, Raisa Haavikko, Tuomo Laitinen, Dina Navia-Paldanius, Roosa Rytilahti, Miia Vaara, Marko Lehtonen, Sami Alakurtti, Jari Yli-Kauhaluoma, Tapio Nevalainen, Juha R Savinainen, Jarmo T Laitinen
Published 2014-01-01

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

by Christopher R. M. Asquith, James M. Bennett, Lianyong Su, Tuomo Laitinen, Jonathan M. Elkins, Julie E. Pickett, Carrow I. Wells, Zengbiao Li, Timothy M. Willson, William J. Zuercher
Published 2019-11-01