Pharmacogenetics – challenges and opportunities ahead

by Ulrich M Zanger
Published 2010-08-01

Pharmacogenomics of cytochrome P450 3A4 (CYP3A4): recent progress towards the missing heritability problem

by Kathrin eKlein, Ulrich M Zanger
Published 2013-02-01

Pharmacogenetics of Cytochrome P450 2B6 (CYP2B6): Advances on Polymorphisms, Mechanisms, and Clinical Relevance

by Ulrich M Zanger, Kathrin eKlein
Published 2013-03-01

Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

by Tamara Heintze, Kathrin Klein, Ute Hofmann, Ulrich M. Zanger
Published 2021-01-01

MIRNA-DISTILLER: a stand-alone application to compile microRNA data from databases

by Jessica K. Rieger, Denis A. Bodan, Ulrich M Zanger
Published 2011-07-01

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

by Amit V. Pandey, Amit V. Pandey, Colin J. Henderson, Yuji Ishii, Michel Kranendonk, Wayne L. Backes, Ulrich M. Zanger, Ulrich M. Zanger
Published 2017-11-01

Molecular interactions between NAFLD and xenobiotic metabolism

by Adviti eNaik, Aleš eBelič, Ulrich M Zanger, Damjana eRozman
Published 2013-01-01

Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes

by Maria Thomas, Jessica K. Rieger, Benjamin A. Kandel, Kathrin Klein, Ulrich M. Zanger
Published 2014-07-01

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

by J. E. Zhang, Kathrin Klein, Kathrin Klein, Andrea L. Jorgensen, Ben Francis, Ana Alfirevic, Stephane Bourgeois, Panagiotis Deloukas, Panagiotis Deloukas, Panagiotis Deloukas, Ulrich M. Zanger, Ulrich M. Zanger, Munir Pirmohamed
Published 2017-05-01

LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods.

by Ronny Feuer, Sebastian Vlaic, Janine Arlt, Oliver Sawodny, Uta Dahmen, Ulrich M Zanger, Maria Thomas
Published 2015-01-01

Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.

by Yijing Zhang, Kathrin Klein, Aarathi Sugathan, Najlla Nassery, Alan Dombkowski, Ulrich M Zanger, David J Waxman
Published 2011-01-01

Human Sterol Regulatory Element-Binding Protein 1a Contributes Significantly to Hepatic Lipogenic Gene Expression

by Andreas Bitter, Andreas K. Nüssler, Wolfgang E. Thasler, Kathrin Klein, Ulrich M. Zanger, Matthias Schwab, Oliver Burk
Published 2015-01-01

Pathway-targeted pharmacogenomics of CYP1A2 in human liver

by Kathrin eKlein, Stefan eWinter, Miia eTurpeinen, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger
Published 2010-11-01

A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

by Kathrin Klein, Kathrin Klein, Roman Tremmel, Roman Tremmel, Stefan Winter, Stefan Winter, Sarah Fehr, Sarah Fehr, Florian Battke, Florian Battke, Tim Scheurenbrand, Tim Scheurenbrand, Elke Schaeffeler, Elke Schaeffeler, Saskia Biskup, Saskia Biskup, Matthias Schwab, Matthias Schwab, Matthias Schwab, Matthias Schwab, Ulrich M. Zanger, Ulrich M. Zanger
Published 2019-01-01

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.

by Julia Rex, Ute Albrecht, Christian Ehlting, Maria Thomas, Ulrich M Zanger, Oliver Sawodny, Dieter Häussinger, Michael Ederer, Ronny Feuer, Johannes G Bode
Published 2016-07-01

Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells

by Lisa Goedtke, Heike Sprenger, Ute Hofmann, Felix F. Schmidt, Helen S. Hammer, Ulrich M. Zanger, Oliver Poetz, Albrecht Seidel, Albert Braeuning, Stefanie Hessel-Pras
Published 2021-12-01

Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling.

by Roland Keller, Marcus Klein, Maria Thomas, Andreas Dräger, Ute Metzger, Markus F Templin, Thomas O Joos, Wolfgang E Thasler, Andreas Zell, Ulrich M Zanger
Published 2016-01-01

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

by Maria eThomas, Stefan eWinter, Britta eKlumpp, Miia eTurpeinen, Kathrin eKlein, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger
Published 2015-11-01

Paraoxonase (PON1 and PON3) polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis

by Stephan eRiedmaier, Kathrin eKlein, Stefan eWinter, Ute eHofmann, Matthias eSchwab, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger
Published 2011-07-01

Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression

by Hannah Asperger, Nadia Stamm, Berthold Gierke, Michael Pawlak, Ute Hofmann, Ulrich M. Zanger, Annamaria Marton, Robert L. Katona, Andrea Buhala, Csaba Vizler, Jan-Philipp Cieslik, Eugen Ruckhäberle, Dieter Niederacher, Tanja Fehm, Hans Neubauer, Marina Ludescher
Published 2020-07-01