PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages

by James Gallant, James Gallant, Tiaan Heunis, Tiaan Heunis, Caroline Beltran, Karin Schildermans, Sven Bruijns, Inge Mertens, Wilbert Bitter, Wilbert Bitter, Samantha L. Sampson
Published 2021-07-01

New Insights into the Regulation of Cell-Surface Signaling Activity Acquired from a Mutagenesis Screen of the Pseudomonas putida IutY Sigma/Anti-Sigma Factor

by María A. Llamas, Karlijn C. Bastiaansen, Karlijn C. Bastiaansen, Cristina Civantos, Wilbert Bitter
Published 2017-05-01

Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death.

by Roxane Simeone, Alexandre Bobard, Juliane Lippmann, Wilbert Bitter, Laleh Majlessi, Roland Brosch, Jost Enninga
Published 2012-02-01

Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier

by Maroeska J. Burggraaf, Louis S. Ates, Alexander Speer, Kim van der Kuij, Coen Kuijl, Wilbert Bitter
Published 2019-03-01

Mutagenesis-Based Characterization and Improvement of a Novel Inclusion Body Tag

by Wouter S. P. Jong, Wouter S. P. Jong, Corinne M. ten Hagen-Jongman, David Vikström, Wendy Dontje, Abdallah M. Abdallah, Abdallah M. Abdallah, Jan-Willem de Gier, Wilbert Bitter, Wilbert Bitter, Joen Luirink, Joen Luirink
Published 2020-01-01

Functional dissection of the PE domain responsible for translocation of PE_PGRS33 across the mycobacterial cell wall.

by Alessandro Cascioferro, Maria H Daleke, Marcello Ventura, Valentina Donà, Giovanni Delogu, Giorgio Palù, Wilbert Bitter, Riccardo Manganelli
Published 2011-01-01

A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa.

by María A Llamas, Astrid van der Sar, Byron C H Chu, Marion Sparrius, Hans J Vogel, Wilbert Bitter
Published 2009-09-01

A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline

by Michaela Wenzel, Marien P. Dekker, Biwen Wang, Maroeska J. Burggraaf, Wilbert Bitter, Jan R. T. van Weering, Leendert W. Hamoen
Published 2021-03-01

The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity.

by Dennapa Saeloh, Varomyalin Tipmanee, Kin Ki Jim, Marien P Dekker, Wilbert Bitter, Supayang P Voravuthikunchai, Michaela Wenzel, Leendert W Hamoen
Published 2018-02-01

Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease

by Maroeska J. Burggraaf, Alexander Speer, Aniek S. Meijers, Roy Ummels, Astrid M. van der Sar, Konstantin V. Korotkov, Wilbert Bitter, Coenraad Kuijl
Published 2019-10-01

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes

by Vincent J. C. van Winden, Roy Ummels, Sander R. Piersma, Connie R. Jiménez, Konstantin V. Korotkov, Wilbert Bitter, Edith N. G. Houben
Published 2016-10-01

Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose.

by Maikel Boot, Vincent J C van Winden, Marion Sparrius, Robert van de Weerd, Alexander Speer, Roy Ummels, Tige Rustad, David R Sherman, Wilbert Bitter
Published 2017-12-01

Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum

by Lisanne M. van Leeuwen, Martijn van der Kuip, Sameh A. Youssef, Alain de Bruin, Wilbert Bitter, A. Marceline van Furth, Astrid M. van der Sar
Published 2014-09-01

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.

by Louis S Ates, Fadel Sayes, Wafa Frigui, Roy Ummels, Merel P M Damen, Daria Bottai, Marcel A Behr, Jeroen W J van Heijst, Wilbert Bitter, Laleh Majlessi, Roland Brosch
Published 2018-06-01

Comparative Genomic and Transcriptomic Analyses of Mycobacterium kansasii Subtypes Provide New Insights Into Their Pathogenicity and Taxonomy

by Qingtian Guan, Roy Ummels, Fathia Ben-Rached, Yara Alzahid, Mohammad S. Amini, Sabir A. Adroub, Jakko van Ingen, Wilbert Bitter, Abdallah M. Abdallah, Abdallah M. Abdallah, Arnab Pain, Arnab Pain
Published 2020-03-01

Impact of protein domains on PE_PGRS30 polar localization in Mycobacteria.

by Flavio De Maio, Giuseppe Maulucci, Mariachiara Minerva, Saber Anoosheh, Ivana Palucci, Raffaella Iantomasi, Valentina Palmieri, Serena Camassa, Michela Sali, Maurizio Sanguinetti, Wilbert Bitter, Riccardo Manganelli, Marco De Spirito, Giovanni Delogu
Published 2014-01-01

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcr...

by Abdallah M Abdallah, Abdallah M Abdallah, Eveline M Weerdenburg, Qingtian Guan, Roy Ummels, Stephanie Borggreve, Sabir A Adroub, Tareq B Malas, Raeece Naeem, Huoming Zhang, Thomas D Otto, Wilbert Bitter, Arnab Pain
Published 2019-01-01

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

by Esther J. M. Stoop, Tim Schipper, Sietske K. Rosendahl Huber, Alexander E. Nezhinsky, Fons J. Verbeek, Sudagar S. Gurcha, Gurdyal S. Besra, Christina M. J. E. Vandenbroucke-Grauls, Wilbert Bitter, Astrid M. van der Sar
Published 2011-07-01

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

by Matthias I. Gröschel, Fadel Sayes, Sung Jae Shin, Wafa Frigui, Alexandre Pawlik, Mickael Orgeur, Robin Canetti, Nadine Honoré, Roxane Simeone, Tjip S. van der Werf, Wilbert Bitter, Sang-Nae Cho, Laleh Majlessi, Roland Brosch
Published 2017-03-01

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF.

by Trang H Phan, Lisanne M van Leeuwen, Coen Kuijl, Roy Ummels, Gunny van Stempvoort, Alba Rubio-Canalejas, Sander R Piersma, Connie R Jiménez, Astrid M van der Sar, Edith N G Houben, Wilbert Bitter
Published 2018-08-01