Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings.

by Xuefang Pan, Yanting Wang, Torben Lübke, Aleksander Hinek, Alexey V Pshezhetsky
Published 2017-01-01

Structural basis for substrate specificity of mammalian neuraminidases.

by Victoria Smutova, Amgad Albohy, Xuefang Pan, Elena Korchagina, Taeko Miyagi, Nicolai Bovin, Christopher W Cairo, Alexey V Pshezhetsky
Published 2014-01-01

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

by Anne Fougerat, Xuefang Pan, Victoria Smutova, Nikolaus Heveker, Christopher W. Cairo, Tarik Issad, Bruno Larrivée, Jeffrey A. Medin, Alexey V. Pshezhetsky
Published 2018-06-01

Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1.

by Xuefang Pan, Lubov Grigoryeva, Volkan Seyrantepe, Junzheng Peng, Katrin Kollmann, Johanne Tremblay, Julie L Lavoie, Aleksander Hinek, Torben Lübke, Alexey V Pshezhetsky
Published 2014-02-01

Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression

by Carlos R. Morales, Lubov S. Grigoryeva, Xuefang Pan, Luigi Bruno, Gilles Hickson, Michael H. Ngo, Christopher R. McMaster, Mark E. Samuels, Alexey V. Pshezhetsky
Published 2014-01-01

Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1.

by Elizaveta Katorcha, Nina Klimova, Natallia Makarava, Regina Savtchenko, Xuefang Pan, Ida Annunziata, Kohta Takahashi, Taeko Miyagi, Alexey V Pshezhetsky, Alessandra d'Azzo, Ilia V Baskakov
Published 2015-01-01

Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages

by Ekaterina P. Demina, Victoria Smutova, Xuefang Pan, Anne Fougerat, Tianlin Guo, Chunxia Zou, Radhika Chakraberty, Brendan D. Snarr, Tze C. Shiao, Rene Roy, Alexander N. Orekhov, Taeko Miyagi, Muriel Laffargue, Donald C. Sheppard, Christopher W. Cairo, Alexey V. Pshezhetsky
Published 2021-02-01