The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.

by Karen S Hathcock, Lila Farrington, Irina Ivanova, Ferenc Livak, Roza Selimyan, Ranjan Sen, Joy Williams, Xuguang Tai, Richard J Hodes
Published 2011-01-01

Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation

by Anne Gegonne, Qing-Rong Chen, Anup Dey, Ruth Etzensperger, Xuguang Tai, Alfred Singer, Daoud Meerzaman, Keiko Ozato, Dinah S. Singer
Published 2018-07-01

The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells

by Adam T. Waickman, Hilary R. Keller, Tae-Hyoun Kim, Megan A. Luckey, Xuguang Tai, Changwan Hong, Carmen Molina-París, Scott T.R. Walsh, Jung-Hyun Park
Published 2020-08-01

Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus

by François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Published 2020-06-01