Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro

by Hiroko Iseoka, Shigeru Miyagawa, Yoshiki Sakai, Yoshiki Sawa
Published 2021-07-01

A Novel Long-Acting Prostacyclin Agonist (ONO-1301) With an Angiogenic Effect: Promoting Synthesis of Hepatocyte Growth Factor and Increasing Cyclic AMP Concentration via IP-Recept...

by Takahiro Uchida, Mai Hazekawa, Miyako Yoshida, Kunio Matsumoto, Yoshiki Sakai
Published 2013-01-01

Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT

by Kenta Masada, Shigeru Miyagawa, Yoshiki Sakai, Akima Harada, Tomomitsu Kanaya, Yoshiki Sawa
Published 2020-12-01

Administration of Slow-Release Synthetic Prostacyclin Agonist Promoted Angiogenesis and Skeletal Muscle Regeneration for Limb Ischemia

by Takaya Nakagawa, Shigeru Miyagawa, Takashi Shibuya, Yoshiki Sakai, Akima Harada, Kenichi Watanabe, Yoshiki Sawa
Published 2020-09-01

Enhanced Pulmonary Vascular and Alveolar Development via Prenatal Administration of a Slow-Release Synthetic Prostacyclin Agonist in Rat Fetal Lung Hypoplasia.

by Satoshi Umeda, Shigeru Miyagawa, Satsuki Fukushima, Noriko Oda, Atsuhiro Saito, Yoshiki Sakai, Yoshiki Sawa, Hiroomi Okuyama
Published 2016-01-01

Sustained-release delivery of prostacyclin analogue enhances bone marrow-cell recruitment and yields functional benefits for acute myocardial infarction in mice.

by Yukiko Imanishi, Shigeru Miyagawa, Satsuki Fukushima, Kazuhiko Ishimaru, Nagako Sougawa, Atsuhiro Saito, Yoshiki Sakai, Yoshiki Sawa
Published 2013-01-01

Innovative therapeutic strategy using prostaglandin I2 agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension

by Tomomitsu Kanaya, Shigeru Miyagawa, Takuji Kawamura, Yoshiki Sakai, Kenta Masada, Nobutoshi Nawa, Hidekazu Ishida, Jun Narita, Koichi Toda, Toru Kuratani, Yoshiki Sawa
Published 2021-03-01

A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity

by Yutaka Kakizoe, Yoshikazu Miyasato, Tomoaki Onoue, Terumasa Nakagawa, Manabu Hayata, Kohei Uchimura, Jun Morinaga, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, Masashi Mukoyama, Kenichiro Kitamura
Published 2016-10-01

Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic...

by Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura
Published 2016-02-01

A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats

by Teruhiko Mizumoto, Yutaka Kakizoe, Terumasa Nakagawa, Yasunobu Iwata, Yoshikazu Miyasato, Kohei Uchimura, Masataka Adachi, Qinyuan Deng, Manabu Hayata, Jun Morinaga, Taku Miyoshi, Yuichiro Izumi, Takashige Kuwabara, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura, Masashi Mukoyama
Published 2021-08-01

Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats

by Shin Yajima, MD, PhD, Shigeru Miyagawa, MD, PhD, Satsuki Fukushima, MD, PhD, Yoshiki Sakai, BSc, Hiroko Iseoka, PhD, Akima Harada, BSc, Kayako Isohashi, MD, PhD, Genki Horitsugi, BSc, Yuki Mori, PhD, Motoko Shiozaki, PhD, Hirotatsu Ohkawara, PhD, Ryoto Sakaniwa, PhD, Jun Hatazawa, MD, PhD, Yoshichika Yoshioka, PhD, Yoshiki Sawa, MD, PhD
Published 2019-06-01