A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model

by Hendrik Wesseling, Ype Elgersma, Sabine Bahn
Published 2017-08-01

Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome

by Tiantian Wang, Geeske M. van Woerden, Geeske M. van Woerden, Ype Elgersma, Ype Elgersma, J. Gerard G. Borst
Published 2018-01-01

α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns.

by Jeiwon Cho, Rushi Bhatt, Ype Elgersma, Alcino J Silva
Published 2012-01-01

Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome

by Monica Sonzogni, Peipei Zhai, Edwin J. Mientjes, Geeske M. van Woerden, Ype Elgersma
Published 2020-09-01

The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons

by Ilaria Tonazzini, Geeske M. Van Woerden, Cecilia Masciullo, Edwin J. Mientjes, Ype Elgersma, Marco Cecchini
Published 2019-11-01

A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants

by Monica Sonzogni, Ilse Wallaard, Sara Silva Santos, Jenina Kingma, Dorine du Mee, Geeske M. van Woerden, Ype Elgersma
Published 2018-09-01

Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.

by Marlous J Groenewoud, Susan M I Goorden, Jorien Kassies, Wendy Pellis-van Berkel, Richard F Lamb, Ype Elgersma, Fried J T Zwartkruis
Published 2013-01-01

MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders

by Sarah C. Borrie, Ellen Plasschaert, Zsuzsanna Callaerts-Vegh, Akihiko Yoshimura, Rudi D’Hooge, Ype Elgersma, Steven A. Kushner, Eric Legius, Hilde Brems
Published 2021-07-01

Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes

by Monica Sonzogni, Johanna Hakonen, Mireia Bernabé Kleijn, Sara Silva-Santos, Matthew C. Judson, Benjamin D. Philpot, Geeske M. van Woerden, Ype Elgersma
Published 2019-05-01

Modulation of Murine Olivary Connexin 36 Gap Junctions by PKA and CaMKII

by Paolo Bazzigaluppi, Sheena C. Isenia, Elize D. Haasdijk, Ype Elgersma, Chris I. De Zeeuw, Ruben S. van der Giessen, Marcel T. G. de Jeu
Published 2017-12-01

Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients.

by Nico J M van Beveren, Gabrielle H S Buitendijk, Sigrid Swagemakers, Lianne C Krab, Christian Röder, Lieuwe de Haan, Peter van der Spek, Ype Elgersma
Published 2012-01-01

Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models

by Jadwiga Schreiber, Laura-Anne Grimbergen, Iris Overwater, Thijs van der Vaart, Jeffrey Stedehouder, Alberto J. Schuhmacher, Carmen Guerra, Steven A. Kushner, Dick Jaarsma, Ype Elgersma
Published 2017-04-01

Effects of antiepileptic drugs in a new TSC/mTOR‐dependent epilepsy mouse model

by Linda M. C. Koene, Saskia E. vanGrondelle, Martina Proietti Onori, Ilse Wallaard, Nathalie H. R. M. Kooijman, Annabel vanOort, Jadwiga Schreiber, Ype Elgersma
Published 2019-07-01

RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.

by Martina Proietti Onori, Linda M C Koene, Carmen B Schäfer, Mark Nellist, Marcel de Brito van Velze, Zhenyu Gao, Ype Elgersma, Geeske M van Woerden
Published 2021-05-01

Correction: Functional Gene-Expression Analysis Shows Involvement of Schizophrenia-Relevant Pathways in Patients with 22q11 Deletion Syndrome

by Nico J. M. van Beveren, Lianne C. Krab, Sigrid Swagemakers, Gabriëe H.S. Buitendijk, Erik Boot, Peter van der Spek, Ype Elgersma, Therese A. M. J. van Amelsvoort
Published 2012-01-01

Functional gene-expression analysis shows involvement of schizophrenia-relevant pathways in patients with 22q11 deletion syndrome.

by Nico J M van Beveren, Lianne C Krab, Sigrid Swagemakers, Gabriëlle H S Buitendijk, Erik Boot, Peter van der Spek, Ype Elgersma, Therese A M J van Amelsvoort
Published 2012-01-01

Correction: Functional Gene-Expression Analysis Shows Involvement of Schizophrenia-Relevant Pathways in Patients with 22q11 Deletion Syndrome.

by Nico J. M. van Beveren, Lianne C. Krab, Sigrid Swagemakers, Gabriëe H.S. Buitendijk, Erik Boot, Peter van der Spek, Ype Elgersma, Therese A. M. J. van Amelsvoort
Published 2012-01-01

A novel UBE3A sequence variant identified in eight related individuals with neurodevelopmental delay, results in a phenotype which does not match the clinical criteria of Angelman...

by Amber Geerts‐Haages, Stijn N. V. Bossuyt, Inge denBesten, Hennie Bruggenwirth, Ineke van derBurgt, Helger G. Yntema, A. Mattijs Punt, Alice Brooks, Ype Elgersma, Ben Distel, Marlies Valstar
Published 2020-11-01

Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function

by Rossella Avagliano Trezza, A. Mattijs Punt, Edwin Mientjes, Marlene van den Berg, F. Isabella Zampeta, Ilona J. de Graaf, Yana van der Weegen, Jeroen A. A. Demmers, Ype Elgersma, Ben Distel
Published 2021-02-01

Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor

by Raman Kumar, Elizabeth Palmer, Elizabeth Palmer, Alison E. Gardner, Renee Carroll, Siddharth Banka, Siddharth Banka, Ola Abdelhadi, Dian Donnai, Dian Donnai, Ype Elgersma, Ype Elgersma, Cynthia J. Curry, Alice Gardham, Mohnish Suri, Rishikesh Malla, Lauren Ilana Brady, Mark Tarnopolsky, Dimitar N. Azmanov, Dimitar N. Azmanov, Vanessa Atkinson, Vanessa Atkinson, Michael Black, Michael Black, Gareth Baynam, Lauren Dreyer, Lauren Dreyer, Robin Z. Hayeems, Christian R. Marshall, Gregory Costain, Marja W. Wessels, Julia Baptista, James Drummond, Melanie Leffler, Michael Field, Jozef Gecz, Jozef Gecz
Published 2020-02-01