Endoplasmic Reticulum Stress-Related Inflammation and Cardiovascular Diseases

by Tomomi Gotoh, Motoyoshi Endo, Yuichi Oike
Published 2011-01-01

TMEM65 is a mitochondrial inner-membrane protein

by Naotaka Nishimura, Tomomi Gotoh, Yuichi Oike, Masato Yano
Published 2014-04-01

Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion

by Kazuki Sugimoto, Takayuki Nakamura, Takuya Tokunaga, Yusuke Uehara, Tatsuya Okada, Takuya Taniwaki, Toru Fujimoto, Yuichi Oike, Eiichi Nakamura
Published 2019-06-01

Macrophage-Derived Angiopoietin-Like Protein 2 Exacerbates Brain Damage by Accelerating Acute Inflammation after Ischemia-Reperfusion.

by Toshihiro Amadatsu, Jun Morinaga, Takayuki Kawano, Kazutoyo Terada, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Daiki Kasamo, Jun-Ichi Kuratsu, Yuichi Oike
Published 2016-01-01

The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases

by Takashi Minami, Shuying Jiang, Keri Schadler, Jun-ichi Suehiro, Tsuyoshi Osawa, Yuichi Oike, Mai Miura, Makoto Naito, Tatsuhiko Kodama, Sandra Ryeom
Published 2013-08-01

Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia

by Shuoyu Wei, Takayuki Isagawa, Masamichi Eguchi, Daisuke Sato, Hiroto Tsukano, Keishi Miyata, Yuichi Oike, Norihiko Takeda, Satoshi Ikeda, Hiroaki Kawano, Koji Maemura
Published 2020-11-01

Increased oxidative stress impairs adipose tissue function in sphingomyelin synthase 1 null mice.

by Masato Yano, Tadashi Yamamoto, Naotaka Nishimura, Tomomi Gotoh, Ken Watanabe, Kazutaka Ikeda, Yohei Garan, Ryo Taguchi, Koichi Node, Toshiro Okazaki, Yuichi Oike
Published 2013-01-01

Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy.

by Shunshun Zhu, Zhe Tian, Daisuke Torigoe, Jiabin Zhao, Peiyu Xie, Taichi Sugizaki, Michio Sato, Haruki Horiguchi, Kazutoyo Terada, Tsuyoshi Kadomatsu, Keishi Miyata, Yuichi Oike
Published 2019-01-01

Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.

by Takayuki Nakamura, Tatsuya Okada, Motoyoshi Endo, Tsuyoshi Kadomatsu, Takuya Taniwaki, Akira Sei, Haruki Odagiri, Tetsuro Masuda, Toru Fujimoto, Takafumi Nakamura, Yuichi Oike, Hiroshi Mizuta
Published 2014-01-01

A molecular clock regulates angiopoietin-like protein 2 expression.

by Tsuyoshi Kadomatsu, Shota Uragami, Makoto Akashi, Yoshiki Tsuchiya, Hiroo Nakajima, Yukiko Nakashima, Motoyoshi Endo, Keishi Miyata, Kazutoyo Terada, Takeshi Todo, Koichi Node, Yuichi Oike
Published 2013-01-01

Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.

by Yohsuke Hanaoka, Osamu Yasuda, Hirofumi Soejima, Keishi Miyata, Eiichiro Yamamoto, Yasuhiro Izumiya, Nobuyo Maeda, Mitsuru Ohishi, Hiromi Rakugi, Yuichi Oike, Shokei Kim-Mitsuyama, Hisao Ogawa
Published 2014-01-01

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.

by Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa
Published 2016-09-01

Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.

by Jun Morinaga, Jiabin Zhao, Motoyoshi Endo, Tsuyoshi Kadomatsu, Keishi Miyata, Taichi Sugizaki, Yusuke Okadome, Zhe Tian, Haruki Horiguchi, Kazuya Miyashita, Nobuhiro Maruyama, Masashi Mukoyama, Yuichi Oike
Published 2018-01-01

Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality

by Taichi Sugizaki, Shunshun Zhu, Ge Guo, Akiko Matsumoto, Jiabin Zhao, Motoyoshi Endo, Haruki Horiguchi, Jun Morinaga, Zhe Tian, Tsuyoshi Kadomatsu, Keishi Miyata, Hiroshi Itoh, Yuichi Oike
Published 2017-09-01

Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus

by Yunseon Jang, Jun Young Heo, Min Joung Lee, Jiebo Zhu, Changjun Seo, Da Hyun Go, Sung Kyung Yoon, Date Yukari, Yuichi Oike, Jong-Woo Sohn, Minho Shong, Gi Ryang Kweon
Published 2021-03-01

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease

by Md Fakruddin, Fan-Yan Wei, Takeo Suzuki, Kana Asano, Takashi Kaieda, Akiko Omori, Ryoma Izumi, Atsushi Fujimura, Taku Kaitsuka, Keishi Miyata, Kimi Araki, Yuichi Oike, Luca Scorrano, Tsutomu Suzuki, Kazuhito Tomizawa
Published 2018-01-01

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

by Takumi Hirata, Yasumichi Arai, Shinsuke Yuasa, Yukiko Abe, Michiyo Takayama, Takashi Sasaki, Akira Kunitomi, Hiroki Inagaki, Motoyoshi Endo, Jun Morinaga, Kimio Yoshimura, Tetsuo Adachi, Yuichi Oike, Toru Takebayashi, Hideyuki Okano, Nobuyoshi Hirose
Published 2020-07-01

The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis

by Michio Sato, Tsuyoshi Kadomatsu, Keishi Miyata, Junco S. Warren, Zhe Tian, Shunshun Zhu, Haruki Horiguchi, Aman Makaju, Anna Bakhtina, Jun Morinaga, Taichi Sugizaki, Kaname Hirashima, Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, Yoshihiro Komohara, Tomohiko Wakayama, Shinichi Nakagawa, Sarah Franklin, Koichi Node, Kimi Araki, Yuichi Oike
Published 2021-05-01

SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix

by Masatoshi Fukuda, Tatsuya Yoshizawa, Md. Fazlul Karim, Shihab U. Sobuz, Wataru Korogi, Daiki Kobayasi, Hiroki Okanishi, Masayoshi Tasaki, Katsuhiko Ono, Tomohiro Sawa, Yoshifumi Sato, Mami Chirifu, Takeshi Masuda, Teruya Nakamura, Hironori Tanoue, Kazuhisa Nakashima, Yoshihiro Kobashigawa, Hiroshi Morioka, Eva Bober, Sumio Ohtsuki, Yuriko Yamagata, Yukio Ando, Yuichi Oike, Norie Araki, Shu Takeda, Hiroshi Mizuta, Kazuya Yamagata
Published 2018-07-01

ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

by Zhe Tian, Keishi Miyata, Tsuyoshi Kadomatsu, Haruki Horiguchi, Hiroyuki Fukushima, Shugo Tohyama, Yoshihiro Ujihara, Takahiro Okumura, Satoshi Yamaguchi, Jiabin Zhao, Motoyoshi Endo, Jun Morinaga, Michio Sato, Taichi Sugizaki, Shunshun Zhu, Kazutoyo Terada, Hisashi Sakaguchi, Yoshihiro Komohara, Motohiro Takeya, Naoki Takeda, Kimi Araki, Ichiro Manabe, Keiichi Fukuda, Kinya Otsu, Jun Wada, Toyoaki Murohara, Satoshi Mohri, Jun K. Yamashita, Motoaki Sano, Yuichi Oike
Published 2016-09-01