The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression

The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression

One of the major life-threatening infections for which severely immunocompromised patients are at risk is invasive aspergillosis (IA). Despite the current treatment options, the increasing antifungal resistance and poor outcome highlight the need for novel therapeutic strategies to improve outcome o...

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Bibliographic Details
Main Authors: Mark S. Gresnigt, Martin Jaeger, R. K. Subbarao Malireddi, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Willem J. G. Melchers, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdonk
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
NOD1
Aspergillus fumigatus
nucleotide-binding oligomerization domain
dectin-1
fungal killing
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01777/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01777/full

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