Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation

Abstract Epigenetic alterations are associated with normal biological processes such as aging or differentiation. Changes in global epigenetic signatures, together with genetic alterations, are driving events in several diseases including cancer. Comparative studies of cancer and healthy tissues fou...

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Bibliographic Details
Main Authors: Daniela Mancarella, Christoph Plass
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Genome Medicine
Subjects:
Online Access:https://doi.org/10.1186/s13073-021-00837-7