The Art and Science of Selecting a CD123-Specific Chimeric Antigen Receptor for Clinical Testing

The Art and Science of Selecting a CD123-Specific Chimeric Antigen Receptor for Clinical Testing

Chimeric antigen receptor (CAR) T cells targeting CD123, an acute myeloid leukemia (AML) antigen, hold the promise of improving outcomes for patients with refractory/recurrent disease. We generated five lentiviral vectors encoding CD20, which may serve as a target for CAR T cell depletion, and 2nd o...

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Bibliographic Details
Main Authors: Janice M. Riberdy, Sheng Zhou, Fei Zheng, Young-In Kim, Jennifer Moore, Abishek Vaidya, Robert E. Throm, April Sykes, Natasha Sahr, Challice L. Bonifant, Byoung Ryu, Stephen Gottschalk, Mireya Paulina Velasquez
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
immunotherapy
CAR
T cell therapy
AML
CD123
leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301480

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http://www.sciencedirect.com/science/article/pii/S2329050120301480

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