Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy

Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy

Abstract Background Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane protein sarcospan (SSPN) in the DMD mdx mouse model significantly reduces disease pathology by restoring membrane adhesion. Ide...

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Bibliographic Details
Main Authors: Cynthia Shu, Ariana N. Kaxon-Rupp, Judd R. Collado, Robert Damoiseaux, Rachelle H. Crosbie
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Skeletal Muscle
Subjects:
Drug discovery
Duchenne muscular dystrophy
C2C12
Dystrophin
Felodipine
High-throughput screen
Online Access:https://doi.org/10.1186/s13395-019-0218-x

Internet

https://doi.org/10.1186/s13395-019-0218-x

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