A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

by Chiara Ghezzi, Alicia Wong, Bao Ying Chen, Bernard Ribalet, Robert Damoiseaux, Peter M. Clark
Published 2019-11-01

Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy

by Cynthia Shu, Ariana N. Kaxon-Rupp, Judd R. Collado, Robert Damoiseaux, Rachelle H. Crosbie
Published 2019-12-01

Large-scale chemical similarity networks for target profiling of compounds identified in cell-based chemical screens.

by Yu-Chen Lo, Silvia Senese, Chien-Ming Li, Qiyang Hu, Yong Huang, Robert Damoiseaux, Jorge Z Torres
Published 2015-03-01

High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy

by Cynthia Shu, Liubov Parfenova, Ekaterina Mokhonova, Judd R. Collado, Robert Damoiseaux, Jesus Campagna, Varghese John, Rachelle H. Crosbie
Published 2020-09-01

Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials.

by Rong Liu, Sijie Lin, Robert Rallo, Yan Zhao, Robert Damoiseaux, Tian Xia, Shuo Lin, Andre Nel, Yoram Cohen
Published 2012-01-01

When more is less: Emergent suppressive interactions in three-drug combinations

by Casey Beppler, Elif Tekin, Cynthia White, Zhiyuan Mao, Jeffrey H. Miller, Robert Damoiseaux, Van M. Savage, Pamela J. Yeh
Published 2017-05-01

A comparative assessment of antiproliferative properties of resveratrol and ethanol leaf extract of Anogeissus leiocarpus (DC) Guill and Perr against HepG2 hepatocarcinoma cells

by Jeremiah Olorunjuwon Olugbami, Robert Damoiseaux, Bryan France, Esther Modupe Onibiyo, Michael Adedapo Gbadegesin, Shivani Sharma, James Kazimierz Gimzewski, Oyeronke Adunni Odunola
Published 2017-08-01

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers

by Shili Xu, Arthur Catapang, Daniel Braas, Linsey Stiles, Hanna M. Doh, Jason T. Lee, Thomas G. Graeber, Robert Damoiseaux, Orian Shirihai, Harvey R. Herschman
Published 2018-06-01

Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry.

by Aria Eshraghi, Shandee D Dixon, Batcha Tamilselvam, Emily Jin-Kyung Kim, Amandeep Gargi, Julia C Kulik, Robert Damoiseaux, Steven R Blanke, Kenneth A Bradley
Published 2014-07-01

A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy

by Jian Liu, Jesus Campagna, Varghese John, Robert Damoiseaux, Ekaterina Mokhonova, Diana Becerra, Huan Meng, Elizabeth M. McNally, April D. Pyle, Irina Kramerova, Melissa J. Spencer
Published 2020-10-01

Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.

by Thu P Huynh, Sonali P Barwe, Seung J Lee, Ryan McSpadden, Omar E Franco, Simon W Hayward, Robert Damoiseaux, Stephen S Grubbs, Nicholas J Petrelli, Ayyappan K Rajasekaran
Published 2015-01-01

Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.

by Pamela Y Ting, Robert Damoiseaux, Björn Titz, Kenneth A Bradley, Thomas G Graeber, Virneliz Fernández-Vega, Thomas D Bannister, Peter Chase, Reji Nair, Louis Scampavia, Peter Hodder, Timothy P Spicer, John Colicelli
Published 2015-01-01

High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis

by Cody J. Aros, Manash K. Paul, Carla J. Pantoja, Bharti Bisht, Luisa K. Meneses, Preethi Vijayaraj, Jenna M. Sandlin, Bryan France, Jonathan A. Tse, Michelle W. Chen, David W. Shia, Tammy M. Rickabaugh, Robert Damoiseaux, Brigitte N. Gomperts
Published 2020-02-01

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

by Peter J. Mullen, Gustavo Garcia, Arunima Purkayastha, Nedas Matulionis, Ernst W. Schmid, Milica Momcilovic, Chandani Sen, Justin Langerman, Arunachalam Ramaiah, David B. Shackelford, Robert Damoiseaux, Samuel W. French, Kathrin Plath, Brigitte N. Gomperts, Vaithilingaraja Arumugaswami, Heather R. Christofk
Published 2021-03-01

PTPσ inhibitors promote hematopoietic stem cell regeneration

by Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute
Published 2019-08-01

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

by Angel Garcia-Diaz, Daniel Sanghoon Shin, Blanca Homet Moreno, Justin Saco, Helena Escuin-Ordinas, Gabriel Abril Rodriguez, Jesse M. Zaretsky, Lu Sun, Willy Hugo, Xiaoyan Wang, Giulia Parisi, Cristina Puig Saus, Davis Y. Torrejon, Thomas G. Graeber, Begonya Comin-Anduix, Siwen Hu-Lieskovan, Robert Damoiseaux, Roger S. Lo, Antoni Ribas
Published 2017-05-01

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

by Momoko Watanabe, Jessie E. Buth, Neda Vishlaghi, Luis de la Torre-Ubieta, Jiannis Taxidis, Baljit S. Khakh, Giovanni Coppola, Caroline A. Pearson, Ken Yamauchi, Danyang Gong, Xinghong Dai, Robert Damoiseaux, Roghiyh Aliyari, Simone Liebscher, Katja Schenke-Layland, Christine Caneda, Eric J. Huang, Ye Zhang, Genhong Cheng, Daniel H. Geschwind, Peyman Golshani, Ren Sun, Bennett G. Novitch
Published 2017-10-01

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule

by Preethi Vijayaraj, Aspram Minasyan, Abdo Durra, Saravanan Karumbayaram, Mehrsa Mehrabi, Cody J. Aros, Sarah D. Ahadome, David W. Shia, Katherine Chung, Jenna M. Sandlin, Kelly F. Darmawan, Kush V. Bhatt, Chase C. Manze, Manash K. Paul, Dan C. Wilkinson, Weihong Yan, Amander T. Clark, Tammy M. Rickabaugh, W. Dean Wallace, Thomas G. Graeber, Robert Damoiseaux, Brigitte N. Gomperts
Published 2019-12-01