AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice

AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice

Objective: Type 1 diabetes is characterized by autoimmune destruction of β-cells leading to severe insulin deficiency. Although many improvements have been made in recent years, exogenous insulin therapy is still imperfect; new therapeutic approaches, focusing on preserving/expanding β-cell mass and...

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Bibliographic Details
Main Authors: Cristina Mallol, Estefania Casana, Veronica Jimenez, Alba Casellas, Virginia Haurigot, Claudia Jambrina, Victor Sacristan, Meritxell Morró, Judith Agudo, Laia Vilà, Fatima Bosch
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Molecular Metabolism
Subjects:
Autoimmune diabetes
NOD
IGF1
Pancreas
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817302041

Internet

http://www.sciencedirect.com/science/article/pii/S2212877817302041

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