Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

Summary: Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin sensitivity, which may mediate the beneficial effects of a CR diet. This model has been challenged by the identification of interventio...

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Bibliographic Details
Main Authors: Deyang Yu, Jay L. Tomasiewicz, Shany E. Yang, Blake R. Miller, Matthew H. Wakai, Dawn S. Sherman, Nicole E. Cummings, Emma L. Baar, Jacqueline A. Brinkman, Faizan A. Syed, Dudley W. Lamming
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719311465

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http://www.sciencedirect.com/science/article/pii/S2211124719311465

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