Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Abstract Pathogenic mutations in the tau gene (microtubule associated protein tau, MAPT) are linked to the onset of tauopathy, but the A152T variant is unique in acting as a risk factor for a range of disorders including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), corticobasal de...

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Bibliographic Details
Main Authors: Yari Carlomagno, Dah-eun Chloe Chung, Mei Yue, Aishe Kurti, Nicole M. Avendano, Monica Castanedes-Casey, Kelly M. Hinkle, Karen Jansen-West, Lillian M. Daughrity, Jimei Tong, Virginia Phillips, Rosa Rademakers, Michael DeTure, John D. Fryer, Dennis W. Dickson, Leonard Petrucelli, Casey Cook
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Acta Neuropathologica Communications
Subjects:
Tauopathy
A152T
Phosphorylation
Solubility
Risk factor
Neuropathology
Online Access:http://link.springer.com/article/10.1186/s40478-019-0661-2

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http://link.springer.com/article/10.1186/s40478-019-0661-2

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