Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

G-quadruplexes (G4) are extremely stable secondary structures forming stacks of guanine tetrads. DNA G4 structures have been extensively studied, however, less is known about G4 motifs in mRNAs, especially in their coding sequences. Herein, we show that Aven stimulates the mRNA translation of the mi...

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Bibliographic Details
Main Authors: Palaniraja Thandapani, Jingwen Song, Valentina Gandin, Yutian Cai, Samuel G Rouleau, Jean-Michel Garant, Francois-Michel Boisvert, Zhenbao Yu, Jean-Pierre Perreault, Ivan Topisirovic, Stéphane Richard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
G-quadruplex
arginine methylation
PRMT1
RNA-binding protein
translation
Online Access:https://elifesciences.org/articles/06234

Internet

https://elifesciences.org/articles/06234

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