Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

The aberrant aggregation of proteins is implicated in the onset and pathogenesis of a wide range of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Mounting evidence indicates that misfolded protein oligomers produced as intermediates in the aggregation process are poten...

Full description

Bibliographic Details
Main Authors: Ryan P. Kreiser, Aidan K. Wright, Natalie R. Block, Jared E. Hollows, Lam T. Nguyen, Kathleen LeForte, Benedetta Mannini, Michele Vendruscolo, Ryan Limbocker
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
misfolded protein oligomers
countermeasures
kinetics
structure–toxicity relationships
membrane protection
protein homeostasis
Online Access:https://www.mdpi.com/1422-0067/21/22/8651

Internet

https://www.mdpi.com/1422-0067/21/22/8651

Similar Items