The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice

The human cytokine interleukin (IL)-37 has potent anti-inflammatory capacities, and hematopoietic cell-specific transgenic overexpression of IL-37 in mice protects against septic shock and colitis. In the present study we investigated the effect of hematopoietic expression of IL-37 on atherosclerosi...

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Bibliographic Details
Main Authors: Geerte Hoeke, P. Padmini S.J. Khedoe, Janna A. van Diepen, Karin Pike-Overzet, Britt van de Ven, Nadia Vazirpanah, Isabel Mol, Pieter S. Hiemstra, Frank J.T. Staal, Rinke Stienstra, Mihai G. Netea, Charles A. Dinarello, Patrick C.N. Rensen, Jimmy F.P. Berbée
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:International Journal of Molecular Sciences
Subjects:
atherosclerosis
inflammation
interleukin-37
hyperlipidemia
Online Access:https://www.mdpi.com/1422-0067/18/8/1672

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https://www.mdpi.com/1422-0067/18/8/1672

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