The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice
The human cytokine interleukin (IL)-37 has potent anti-inflammatory capacities, and hematopoietic cell-specific transgenic overexpression of IL-37 in mice protects against septic shock and colitis. In the present study we investigated the effect of hematopoietic expression of IL-37 on atherosclerosi...
Main Authors: | Geerte Hoeke, P. Padmini S.J. Khedoe, Janna A. van Diepen, Karin Pike-Overzet, Britt van de Ven, Nadia Vazirpanah, Isabel Mol, Pieter S. Hiemstra, Frank J.T. Staal, Rinke Stienstra, Mihai G. Netea, Charles A. Dinarello, Patrick C.N. Rensen, Jimmy F.P. Berbée |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/18/8/1672 |
Similar Items
-
Brown adipose tissue takes up plasma triglycerides mostly after lipolysis
by: Padmini P.S.J. Khedoe, et al.
Published: (2015-01-01) -
IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake
by: Eline N. Kuipers, et al.
Published: (2018-08-01) -
Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice[S]
by: Janna A. van Diepen, et al.
Published: (2011-05-01) -
Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche
by: Parisa Tajer, et al.
Published: (2019-02-01) -
Interstitial Lung Disease in Patients With Systemic Sclerosis: Toward Personalized-Medicine-Based Prediction and Drug Screening Models of Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD)
by: Padmini Khedoe, et al.
Published: (2020-09-01)