Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism.

Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism.

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization...

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Bibliographic Details
Main Authors: Sarah Garrido-Urbani, Stephane Jemelin, Christine Deffert, Stéphanie Carnesecchi, Olivier Basset, Cédric Szyndralewiez, Freddy Heitz, Patrick Page, Xavier Montet, Liliane Michalik, Jack Arbiser, Curzio Rüegg, Karl Heinz Krause, Beat A Imhof
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3034713?pdf=render

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http://europepmc.org/articles/PMC3034713?pdf=render

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