Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex

Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex

The synthesis and evaluation of ten new dihydrophthalazine-appended 2,4-diaminopyrimidines as potential drugs to treat Bacillus anthracis is reported. An improved synthesis utilizing a new pincer catalyst, dichlorobis[1-(dicyclohexylphosphanyl)-piperidine]palladium(II), allows the final Heck coupli...

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Bibliographic Details
Main Authors: Nagendra Prasad Muddala, Baskar Nammalwar, Subhashini Selvaraju, Christina R. Bourne, Mary Henry, Richard A. Bunce, K. Darrell Berlin, Esther W. Barrow, William W. Barrow
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Molecules
Subjects:
2,4-diaminopyrimidine antifolates
dihydrofolate reductase (DHFR)
Bacillus anthracis
pincer complexes
Heck coupling
Online Access:http://www.mdpi.com/1420-3049/20/4/7222

Internet

http://www.mdpi.com/1420-3049/20/4/7222

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