Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease

Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease

Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting the nigrostriatal pathway, where patients do not manifest motor symptoms until >50% of neurons are lost. Thus, it is of great importance to determine early neuronal changes that may contribute to disease progressio...

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Bibliographic Details
Main Authors: Kyle Farmer, Catherine A. Smith, Shawn Hayley, Jeffrey Smith
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
lipidomic profile
Parkinson’s disease
early stage model
6-hydroxydopamine
HPLC-ESI-MS/MS
Online Access:http://www.mdpi.com/1422-0067/16/8/18865

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http://www.mdpi.com/1422-0067/16/8/18865

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