Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment

Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment

ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent immune system dysregulation.MethodsWe conducted a...

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Bibliographic Details
Main Authors: Carolin T. Turner, James Brown, Emily Shaw, Imran Uddin, Evdokia Tsaliki, Jennifer K. Roe, Gabriele Pollara, Yuxin Sun, James M. Heather, Marc Lipman, Benny Chain, Mahdad Noursadeghi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus
T cell repertoire
blood transcriptome
antiretroviral therapy
people living with HIV
chronic inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.634489/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.634489/full

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