A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in cell homeostasis as well as in cellular transformati...

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Bibliographic Details
Main Authors: Mary McMahon, Adrian Contreras, Mikael Holm, Tamayo Uechi, Craig M Forester, Xiaming Pang, Cody Jackson, Meredith E Calvert, Bin Chen, David A Quigley, John M Luk, R Kate Kelley, John D Gordan, Ryan M Gill, Scott C Blanchard, Davide Ruggero
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
ribosome
snoRNA
pseudouridine modification
steatohepatitic hepatocellular carcinoma
translation
noncoding RNA
Online Access:https://elifesciences.org/articles/48847

Internet

https://elifesciences.org/articles/48847

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