Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas

Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas

Background: Intra-tumoral CD8 + T-cell infiltration in squamous cell carcinoma of the head and neck (HNSCC) has previously been linked to the efficacy of cisplatin-based chemoradiation (CDDP-CRTX) and immune checkpoint inhibitor (ICI) monotherapy. Further detailed characterization of the tumor immun...

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Bibliographic Details
Main Authors: Anne-Kathrin Hess, Korinna Jöhrens, Andre Zakarneh, Panagiotis Balermpas, Jens Von Der Grün, Claus Rödel, Wilko Weichert, Michael Hummel, Ulrich Keilholz, Volker Budach, Ingeborg Tinhofer
Format: Article
Language:English
Published: Taylor & Francis Group 2019-08-01
Series:OncoImmunology
Subjects:
immune signature
prediction score
prognostic biomarker
radiochemotherapy
head neck cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1614858

Internet

http://dx.doi.org/10.1080/2162402X.2019.1614858

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