From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity

by Guido Gambara, Guido Gambara, Manuela Gaebler, Ulrich Keilholz, Ulrich Keilholz, Christian R. A. Regenbrecht, Alessandra Silvestri
Published 2018-02-01

Liquid biopsy assessment of synchronous malignancies: a case report and review of the literature

by Loredana Vecchione, Sandra Liebs, Anika Nonnenmacher, Frederick Klauschen, Ulrich Keilholz
Published 2019-07-01

Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after...

by Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther, Ulrike Stein
Published 2018-03-01

Detection of mutations in circulating cell‐free DNA in relation to disease stage in colorectal cancer

by Sandra Liebs, Ulrich Keilholz, Inge Kehler, Caroline Schweiger, Johannes Haybäck, Anika Nonnenmacher
Published 2019-07-01

Variant information systems for precision oncology

by Johannes Starlinger, Steffen Pallarz, Jurica Ševa, Damian Rieke, Christine Sers, Ulrich Keilholz, Ulf Leser
Published 2018-11-01

The Evolving Role of Taxanes in Combination With Cetuximab for the Treatment of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck: Evidence, Advantages, and...

by Joël Guigay, Makoto Tahara, Lisa Licitra, Ulrich Keilholz, Signe Friesland, Pauline Witzler, Ricard Mesía
Published 2019-08-01

Primary Extracellular Matrix Enables Long-Term Cultivation of Human Tumor Oral Mucosa Models

by Leonie Gronbach, Philipp Jurmeister, Philipp Jurmeister, Monika Schäfer-Korting, Ulrich Keilholz, Ingeborg Tinhofer, Ingeborg Tinhofer, Christian Zoschke
Published 2020-12-01

Automated Real-Time Tumor Pharmacokinetic Profiling in 3D Models: A Novel Approach for Personalized Medicine

by Jan F. Joseph, Leonie Gronbach, Jill García-Miller, Leticia M. Cruz, Bernhard Wuest, Ulrich Keilholz, Christian Zoschke, Maria K. Parr
Published 2020-04-01

VIST - a Variant-Information Search Tool for precision oncology

by Jurica Ševa, David Luis Wiegandt, Julian Götze, Mario Lamping, Damian Rieke, Reinhold Schäfer, Patrick Jähnichen, Madeleine Kittner, Steffen Pallarz, Johannes Starlinger, Ulrich Keilholz, Ulf Leser
Published 2019-08-01

Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas

by Anne-Kathrin Hess, Korinna Jöhrens, Andre Zakarneh, Panagiotis Balermpas, Jens Von Der Grün, Claus Rödel, Wilko Weichert, Michael Hummel, Ulrich Keilholz, Volker Budach, Ingeborg Tinhofer
Published 2019-08-01

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures.

by Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Jens Hoffmann, Melanie Boerries, Reinhold Schäfer, Christian R A Regenbrecht
Published 2019-03-01

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

by Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Johannes Haybaeck, Ulrich Keilholz, Caroline Schweiger, Nicole Golob-Schwarzl, Dominik Mumberg, David Henderson, Hans Lehrach, Christian R.A. Regenbrecht, Reinhold Schäfer, Martin Lange
Published 2017-12-01

RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

by Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Ralf Lesche, Joern Toedling, Thibaud Jourdan, Johannes Haybaeck, Dominik Mumberg, David Henderson, Balázs Győrffy, Christian R.A. Regenbrecht, Ulrich Keilholz, Reinhold Schäfer, Martin Lange
Published 2021-06-01

Avelumab in patients with previously treated metastatic melanoma: phase 1b results from the JAVELIN Solid Tumor trial

by Ulrich Keilholz, Janice M. Mehnert, Sebastian Bauer, Hugues Bourgeois, Manish R. Patel, Donald Gravenor, John J. Nemunaitis, Matthew H. Taylor, Lucjan Wyrwicz, Keun-Wook Lee, Vijay Kasturi, Kevin Chin, Anja von Heydebreck, James L. Gulley
Published 2019-01-01

Avelumab (anti–PD-L1) as first-line switch-maintenance or second-line therapy in patients with advanced gastric or gastroesophageal junction cancer: phase 1b results from the JAVEL...

by Hyun Cheol Chung, Hendrik-Tobias Arkenau, Jeeyun Lee, Sun Young Rha, Do-Youn Oh, Lucjan Wyrwicz, Yoon-Koo Kang, Keun-Wook Lee, Jeffrey R. Infante, Sung Sook Lee, Margaret Kemeny, Ulrich Keilholz, Bohuslav Melichar, Alain Mita, Ruth Plummer, Denis Smith, Arnold B. Gelb, Huiling Xiong, Janet Hong, Vikram Chand, Howard Safran
Published 2019-02-01

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

by Moritz Schütte, Thomas Risch, Nilofar Abdavi-Azar, Karsten Boehnke, Dirk Schumacher, Marlen Keil, Reha Yildiriman, Christine Jandrasits, Tatiana Borodina, Vyacheslav Amstislavskiy, Catherine L. Worth, Caroline Schweiger, Sandra Liebs, Martin Lange, Hans- Jörg Warnatz, Lee M. Butcher, James E. Barrett, Marc Sultan, Christoph Wierling, Nicole Golob-Schwarzl, Sigurd Lax, Stefan Uranitsch, Michael Becker, Yvonne Welte, Joseph Lewis Regan, Maxine Silvestrov, Inge Kehler, Alberto Fusi, Thomas Kessler, Ralf Herwig, Ulf Landegren, Dirk Wienke, Mats Nilsson, Juan A. Velasco, Pilar Garin-Chesa, Christoph Reinhard, Stephan Beck, Reinhold Schäfer, Christian R. A. Regenbrecht, David Henderson, Bodo Lange, Johannes Haybaeck, Ulrich Keilholz, Jens Hoffmann, Hans Lehrach, Marie-Laure Yaspo
Published 2017-02-01

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

by Enriqueta Felip, Josep Tabernero, Maria De Santis, Emile Voest, Mark Robson, Fatima Cardoso, Elisabeth G E de Vries, Fedro Alessandro Peccatori, Svetlana Jezdic, Giannis Mountzios, Smita Bhatia, Alexandru Eniu, Luzia Travado, Ulrich Keilholz, Jonas Bergh, Jan Buckner, Friedrich Stiefel, Ahmad Awada, Cristiana Sessa, Olivier Michielin, Marc Ernstoff, Ben Markman, Lisa Licitra, Rossana Berardi, Jill Gilbert, Lidia Schapira, Eva Schernhammer, Jeffrey S Weber, Heinz-Josef Lenz, Piotr Rutkowski, Jennifer Duff, Axel Grothey, Yuichiro Ohe, Saskia Litiere, Hans Wildiers, Christian Dittrich, Michael Kosty, Doug Pyle, Nagi El-Saghir, Jean-Pierre Lotz, Pia Österlund, Nicholas Pavlidis, Gunta Purkalne, Susana Banerjee, Jan Bogaerts, Paolo Casali, Edward Chu, Julia Lee Close, Bertrand Coiffier, Roisin Connolly, Sarah Coupland, Luigi De Petris, Don S Dizon, Linda R Duska, Martin F Fey, Nicolas Girard, Andor W J M Glaudemans, Priya K Gopalan, Stephen M Hahn, Diana Hanna, Christian Herold, Jørn Herrstedt, Krisztian Homicsko, Dennie V Jones, Lorenz Jost, Saad Khan, Alexander Kiss, Claus-Henning Köhne, Rainer Kunstfeld, Stuart Lichtman, Thomas Lion, Lifang Liu, Patrick J Loehrer, Merry Jennifer Markham, Marius Mayerhoefer, Johannes G Meran, Elizabeth Charlotte Moser, Timothy Moynihan, Torsten Nielsen, Kjell Öberg, Antonio Palumbo, Michael Pfeilstöcker, Chandrajit Raut, Scot C Remick, Roberto Salgado, Martin Schlumberger, Hans-Joachim Schmoll, Lowell Schnipper, Charles L Shapiro, Julie Steele, Cora N Sternberg, Florian Strasser, Roger Stupp, Richard Sullivan, Marcel Verheij, Everett Vokes, Jamie Von Roenn, Yosef Yarden
Published 2016-09-01