Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction.

by Stefan Legewie, Nils Blüthgen, Reinhold Schäfer, Hanspeter Herzel
Published 2005-10-01

A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report

by Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang, Luying Liu
Published 2018-08-01

Identifying resistance mechanisms against five tyrosine kinase inhibitors targeting the ERBB/RAS pathway in 45 cancer cell lines.

by Zsófia Pénzváltó, Bálint Tegze, A Marcell Szász, Zsófia Sztupinszki, István Likó, Attila Szendrői, Reinhold Schäfer, Balázs Győrffy
Published 2013-01-01

The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells.

by Torben Redmer, Yvonne Welte, Diana Behrens, Iduna Fichtner, Dorothea Przybilla, Wasco Wruck, Marie-Laure Yaspo, Hans Lehrach, Reinhold Schäfer, Christian R A Regenbrecht
Published 2014-01-01

VIST - a Variant-Information Search Tool for precision oncology

by Jurica Ševa, David Luis Wiegandt, Julian Götze, Mario Lamping, Damian Rieke, Reinhold Schäfer, Patrick Jähnichen, Madeleine Kittner, Steffen Pallarz, Johannes Starlinger, Ulrich Keilholz, Ulf Leser
Published 2019-08-01

Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer

by Hagen Kulbe, Raik Otto, Silvia Darb-Esfahani, Hedwig Lammert, Salem Abobaker, Gabriele Welsch, Radoslav Chekerov, Reinhold Schäfer, Duska Dragun, Michael Hummel, Ulf Leser, Jalid Sehouli, Elena Ioana Braicu
Published 2019-07-01

Ras-mediated deregulation of the circadian clock in cancer.

by Angela Relógio, Philippe Thomas, Paula Medina-Pérez, Silke Reischl, Sander Bervoets, Ewa Gloc, Pamela Riemer, Shila Mang-Fatehi, Bert Maier, Reinhold Schäfer, Ulf Leser, Hanspeter Herzel, Achim Kramer, Christine Sers
Published 2014-01-01

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures.

by Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Jens Hoffmann, Melanie Boerries, Reinhold Schäfer, Christian R A Regenbrecht
Published 2019-03-01

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

by Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Johannes Haybaeck, Ulrich Keilholz, Caroline Schweiger, Nicole Golob-Schwarzl, Dominik Mumberg, David Henderson, Hans Lehrach, Christian R.A. Regenbrecht, Reinhold Schäfer, Martin Lange
Published 2017-12-01

RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

by Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Ralf Lesche, Joern Toedling, Thibaud Jourdan, Johannes Haybaeck, Dominik Mumberg, David Henderson, Balázs Győrffy, Christian R.A. Regenbrecht, Ulrich Keilholz, Reinhold Schäfer, Martin Lange
Published 2021-06-01

SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells

by Kathleen Klotz-Noack, Bertram Klinger, Maria Rivera, Natalie Bublitz, Florian Uhlitz, Pamela Riemer, Mareen Lüthen, Thomas Sell, Katharina Kasack, Bastian Gastl, Sylvia S.S. Ispasanie, Tincy Simon, Nicole Janssen, Matthias Schwab, Johannes Zuber, David Horst, Nils Blüthgen, Reinhold Schäfer, Markus Morkel, Christine Sers
Published 2020-09-01

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.

by Karsten Jürchott, Ralf-Jürgen Kuban, Till Krech, Nils Blüthgen, Ulrike Stein, Wolfgang Walther, Christian Friese, Szymon M Kiełbasa, Ute Ungethüm, Per Lund, Thomas Knösel, Wolfgang Kemmner, Markus Morkel, Johannes Fritzmann, Peter M Schlag, Walter Birchmeier, Tammo Krueger, Silke Sperling, Christine Sers, Hans-Dieter Royer, Hanspeter Herzel, Reinhold Schäfer
Published 2010-12-01

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer

by Soulafa Mamlouk, Liam Harold Childs, Daniela Aust, Daniel Heim, Friederike Melching, Cristiano Oliveira, Thomas Wolf, Pawel Durek, Dirk Schumacher, Hendrik Bläker, Moritz von Winterfeld, Bastian Gastl, Kerstin Möhr, Andrea Menne, Silke Zeugner, Torben Redmer, Dido Lenze, Sascha Tierling, Markus Möbs, Wilko Weichert, Gunnar Folprecht, Eric Blanc, Dieter Beule, Reinhold Schäfer, Markus Morkel, Frederick Klauschen, Ulf Leser, Christine Sers
Published 2017-01-01

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

by Moritz Schütte, Thomas Risch, Nilofar Abdavi-Azar, Karsten Boehnke, Dirk Schumacher, Marlen Keil, Reha Yildiriman, Christine Jandrasits, Tatiana Borodina, Vyacheslav Amstislavskiy, Catherine L. Worth, Caroline Schweiger, Sandra Liebs, Martin Lange, Hans- Jörg Warnatz, Lee M. Butcher, James E. Barrett, Marc Sultan, Christoph Wierling, Nicole Golob-Schwarzl, Sigurd Lax, Stefan Uranitsch, Michael Becker, Yvonne Welte, Joseph Lewis Regan, Maxine Silvestrov, Inge Kehler, Alberto Fusi, Thomas Kessler, Ralf Herwig, Ulf Landegren, Dirk Wienke, Mats Nilsson, Juan A. Velasco, Pilar Garin-Chesa, Christoph Reinhard, Stephan Beck, Reinhold Schäfer, Christian R. A. Regenbrecht, David Henderson, Bodo Lange, Johannes Haybaeck, Ulrich Keilholz, Jens Hoffmann, Hans Lehrach, Marie-Laure Yaspo
Published 2017-02-01