Darolutamide antagonizes androgen signaling by blocking enhancer and super‐enhancer activation

by Simon J. Baumgart, Ekaterina Nevedomskaya, Ralf Lesche, Richard Newman, Dominik Mumberg, Bernard Haendler
Published 2020-09-01

Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

by Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Michael Steckel, Ashley L. Eheim, Andrea Haegebarth, Carlo Stresemann
Published 2019-06-01

The Impact of Cand1 in Prostate Cancer

by Andrea Eigentler, Piotr Tymoszuk, Johanna Zwick, Arndt A. Schmitz, Andreas Pircher, Florian Kocher, Andreas Schlicker, Ralf Lesche, Georg Schäfer, Igor Theurl, Helmut Klocker, Isabel Heidegger
Published 2020-02-01

An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases

by Eléonore Bettacchioli, Christelle Le Gaffric, Margaux Mazeas, Maria Orietta Borghi, Johan Frostegard, Guillermo Barturen, Zuzanna Makowska, Sepideh Babei, Ralf Lesche, Pier Luigi Meroni, Marta E. Alarcon-Riquelme, Yves Renaudineau
Published 2021-01-01

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target

by Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Andrea Haegebarth, Antonius ter Laak, Amaury E. Fernández-Montalván, Uwe Eberspaecher, Nicolas D. Werbeck, Ursula Moenning, Stephan Siegel, Bernard Haendler, Ashley L. Eheim, Carlo Stresemann
Published 2020-01-01

RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

by Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Ralf Lesche, Joern Toedling, Thibaud Jourdan, Johannes Haybaeck, Dominik Mumberg, David Henderson, Balázs Győrffy, Christian R.A. Regenbrecht, Ulrich Keilholz, Reinhold Schäfer, Martin Lange
Published 2021-06-01

Identification of Small Molecules that Modulate Mutant p53 Condensation

by Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann
Published 2020-09-01

A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

by Perrine Soret, Christelle Le Dantec, Emiko Desvaux, Nathan Foulquier, Bastien Chassagnol, Sandra Hubert, Christophe Jamin, Guillermo Barturen, Guillaume Desachy, Valérie Devauchelle-Pensec, Cheïma Boudjeniba, Divi Cornec, Alain Saraux, Sandrine Jousse-Joulin, Nuria Barbarroja, Ignasi Rodríguez-Pintó, Ellen De Langhe, Lorenzo Beretta, Carlo Chizzolini, László Kovács, Torsten Witte, PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry Consortium, Eléonore Bettacchioli, Anne Buttgereit, Zuzanna Makowska, Ralf Lesche, Maria Orietta Borghi, Javier Martin, Sophie Courtade-Gaiani, Laura Xuereb, Mickaël Guedj, Philippe Moingeon, Marta E. Alarcón-Riquelme, Laurence Laigle, Jacques-Olivier Pers
Published 2021-06-01