Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal inclusions called Lewy bodies, which are comprised of alpha-synuclein (α-syn). Duplication, triplication or genetic mutations in α-syn (A53T, A30P and E46K) are linked to autosomal dominant PD; thus implicati...

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Bibliographic Details
Main Authors: Katrina L Paumier, Stacey J Sukoff Rizzo, Zdenek Berger, Yi Chen, Cathleen Gonzales, Edward Kaftan, Li Li, Susan Lotarski, Michael Monaghan, Wei Shen, Polina Stolyar, Dmytro Vasilyev, Margaret Zaleska, Warren D Hirst, John Dunlop
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3731353?pdf=render

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http://europepmc.org/articles/PMC3731353?pdf=render

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