AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems. Regulation of mitochondrially produced ROS is required for proper cellular function, adaptation to metabolic stress, and bypassing cellular senescence. Here, we...

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Bibliographic Details
Main Authors: Rebecca C. Rabinovitch, Bozena Samborska, Brandon Faubert, Eric H. Ma, Simon-Pierre Gravel, Sylvia Andrzejewski, Thomas C. Raissi, Arnim Pause, Julie St.-Pierre, Russell G. Jones
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
AMPK
ROS
mitochondria
LKB1
PGC-1α
ULK1
nutrient signaling energy stress
senescence
oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313013

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http://www.sciencedirect.com/science/article/pii/S2211124717313013

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