Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCT

Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCT

Background: In a previous trial we reported that the neuroprotective, anti-inflammatory antibiotic minocycline lessened the negative symptoms of schizophrenia compared with placebo over 1 year. The BeneMin study aimed to replicate this benefit and to determine whether or not there was associated pre...

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Main Authors: Bill Deakin, John Suckling, Paola Dazzan, Eileen Joyce, Stephen M Lawrie, Rachel Upthegrove, Nusrat Husain, Imran B Chaudhry, Graham Dunn, Peter B Jones, Danuta Lisiecka-Ford, Shôn Lewis, Thomas RE Barnes, Steven CR Williams, Carmine M Pariante, Emma Knox, Richard J Drake, Richard Smallman, Nicholas M Barnes
Format: Article
Language:English
Published: NIHR Journals Library 2019-08-01
Series:Efficacy and Mechanism Evaluation
Subjects:
MINOCYCLINE
SCHIZOPHRENIA
INFLAMMATION
CYTOKINES
MAGNETIC RESONANCE SPECTROSCOPY
GREY MATTER VOLUME
Online Access:https://doi.org/10.3310/eme06070

Internet

https://doi.org/10.3310/eme06070

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