Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

Abstract RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood. Here, crystal structures of human DDX21 deter...

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Bibliographic Details
Main Authors: Zijun Chen, Zhengyang Li, Xiaojian Hu, Feiyan Xie, Siyun Kuang, Bowen Zhan, Wenqing Gao, Xiangjun Chen, Siqi Gao, Yang Li, Yongming Wang, Feng Qian, Chen Ding, Jianhua Gan, Chaoneng Ji, Xue‐Wei Xu, Zheng Zhou, Jinqing Huang, Housheng Hansen He, Jixi Li
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Advanced Science
Subjects:
ATPases
crystal structures
DDX21
RNA helicases
viral protein NS1
Online Access:https://doi.org/10.1002/advs.202000532

Internet

https://doi.org/10.1002/advs.202000532

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