Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator

Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator

AimsOur aim was to investigate the effect of nitric oxide (NO)-independent activation of soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model with diastolic dysfunction and in biopsies from human heart failure with preserved ejection fraction (HFpEF).MethodsDahl sa...

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Bibliographic Details
Main Authors: Detmar Kolijn, Árpád Kovács, Melissa Herwig, Mária Lódi, Marcel Sieme, Abdulatif Alhaj, Peter Sandner, Zoltán Papp, Peter H. Reusch, Peter Haldenwang, Ines Falcão-Pires, Wolfgang A. Linke, Kornelia Jaquet, Sophie Van Linthout, Andreas Mügge, Carsten Tschöpe, Nazha Hamdani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
oxidative stress
inflammation
HFPEF
sGC activator
titin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00345/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00345/full

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