THE ANTI-FIBROTIC ACTIONS OF RELAXIN ARE MEDIATED THROUGH A NO-sGC-cGMP-DEPENDENT PATHWAY IN RENAL MYOFIBROBLASTS IN VITRO AND ENHANCED BY THE NO DONOR, DIETHYLAMINE NONOATE

THE ANTI-FIBROTIC ACTIONS OF RELAXIN ARE MEDIATED THROUGH A NO-sGC-cGMP-DEPENDENT PATHWAY IN RENAL MYOFIBROBLASTS IN VITRO AND ENHANCED BY THE NO DONOR, DIETHYLAMINE NONOATE

INTRODUCTION: The anti-fibrotic hormone, relaxin, has been inferred to disrupt TGF-beta1/Smad2 phosphorylation (pSmad2) signal transduction and promote collagen-degrading gelatinase activity via a nitric oxide (NO)-dependent pathway. Here, we determined the extent to which NO, soluble guanylate cycl...

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Bibliographic Details
Main Authors: Chao eWang, Barbara Kathryn Kemp-Harper, Martina eKocan, Sheng Yu eAng, Tim David Hewitson, Chrishan S Samuel
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Pharmacology
Subjects:
Fibrosis
Myofibroblasts
Nitric Oxide
Relaxin
Cell signaling
cGMP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00091/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00091/full

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