PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation

PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation

Nuclear factor-κB (NF-κB) plays a central role in psoriasis and canonical Wnt/β-catenin pathway blunts the immune-mediated inflammatory cascade in psoriasis. Adenosine A2A receptor activation blocks NF-κB and boosts the Wnt/β-catenin signaling. PDRN (Poly...

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Bibliographic Details
Main Authors: Natasha Irrera, Alessandra Bitto, Mario Vaccaro, Federica Mannino, Violetta Squadrito, Giovanni Pallio, Vincenzo Arcoraci, Letteria Minutoli, Antonio Ieni, Maria Lentini, Domenica Altavilla, Francesco Squadrito
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
adenosine a2a receptor
psoriasis
nf-κb
wnt/β-catenin pathway
Online Access:https://www.mdpi.com/1422-0067/21/4/1215

Internet

https://www.mdpi.com/1422-0067/21/4/1215

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