Brain Endothelial P-Glycoprotein Level Is Reduced in Parkinson’s Disease via a Vitamin D Receptor-Dependent Pathway

Brain Endothelial P-Glycoprotein Level Is Reduced in Parkinson’s Disease via a Vitamin D Receptor-Dependent Pathway

The progressive neurodegeneration in Parkinson’s disease (PD) is accompanied by neuroinflammation and endothelial vascular impairment. Although the vitamin D receptor (VDR) is expressed in both dopamine neurons and brain endothelial cells, its role in the regulation of endothelial biology has not be...

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Bibliographic Details
Main Authors: Hyojung Kim, Jeong-Yong Shin, Yun-Song Lee, Seung Pil Yun, Han-Joo Maeng, Yunjong Lee
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
vitamin D receptor
Parkinson’s disease
P-glycoprotein
6-hydroxydopamine
brain endothelium
α-synuclein aggregation
Online Access:https://www.mdpi.com/1422-0067/21/22/8538

Internet

https://www.mdpi.com/1422-0067/21/22/8538

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