Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs

Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our p...

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Bibliographic Details
Main Authors: Min Li, Yasunari Kanda, Takashi Ashihara, Tetsuo Sasano, Yuji Nakai, Masami Kodama, Erina Hayashi, Yuko Sekino, Tetsushi Furukawa, Junko Kurokawa
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Pharmacological Sciences
Subjects:
iPS cells
Arrhythmias
Potassium channels
Electrophysiology
Cardiac ion channels
Mathematical simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300786

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http://www.sciencedirect.com/science/article/pii/S1347861317300786

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