Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

Retroviral vectors, including those derived from gammaretroviruses and lentiviruses, have found their way into the clinical arena and demonstrated remarkable efficacy for the treatment of immunodeficiencies, leukodystrophies, and globinopathies. Despite these successes, gene therapy unfortunately al...

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Bibliographic Details
Main Authors: Luca Biasco, Michael Rothe, Hildegard Büning, Axel Schambach
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
gammaretroviral
lentiviral
vector
insertional mutagenesis
regulatory authorities
clinical translation
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117301092

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http://www.sciencedirect.com/science/article/pii/S2329050117301092

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