MrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions.

Genome-wide proximity ligation based assays such as Hi-C have revealed that eukaryotic genomes are organized into structural units called topologically associating domains (TADs). From a visual examination of the chromosomal contact map, however, it is clear that the organization of the domains is n...

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Bibliographic Details
Main Authors: Koon-Kiu Yan, Shaoke Lou, Mark Gerstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1005647